GSTZ1

GSTZ1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1FW1
Identifiers
Aliases	GSTZ1, GSTZ1-1, MAAI, MAI, glutathione S-transferase zeta 1, MAAID
External IDs	OMIM: 603758; MGI: 1341859; HomoloGene: 7747; GeneCards: GSTZ1; OMA:GSTZ1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	77,331,597 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	87,211,497 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; gonad; ; right testis; ; left testis; ; right adrenal gland; ; muscle of thigh; ; mucosa of transverse colon; ; right adrenal cortex; ; gastrocnemius muscle; ; left adrenal gland;
	Top expressed in
	lactiferous gland; ; white adipose tissue; ; left lobe of liver; ; right kidney; ; brown adipose tissue; ; proximal tubule; ; subcutaneous adipose tissue; ; human kidney; ; intercostal muscle; ; tunica adventitia of aorta;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; glutathione peroxidase activity; glutathione transferase activity; maleylacetoacetate isomerase activity; isomerase activity; catalytic activity; protein homodimerization activity; protein binding; identical protein binding; hydrolase activity, acting on acid halide bonds, in C-halide compounds;
Cellular component	cytoplasm; cytosol; mitochondrion; mitochondrial matrix;
Biological process	aromatic amino acid family metabolic process; metabolism; L-phenylalanine catabolic process; glutathione metabolic process; glutathione derivative biosynthetic process; tyrosine catabolic process; cellular oxidant detoxification; regulation of acetyl-CoA biosynthetic process from pyruvate;
	Sources:Amigo / QuickGO
Orthologs
	2954
	14874
	ENSG00000100577
	ENSMUSG00000021033
	O43708
	Q9WVL0
	NM_001312660; NM_001513; NM_145870; NM_145871; NM_001363703
	NM_001252555; NM_001252556; NM_010363; NM_001364306; NM_001364307
	NP_001299589; NP_665877; NP_665878; NP_001350632
	NP_001239484; NP_001239485; NP_034493; NP_001351235; NP_001351236
	Wikidata
View/Edit Human	View/Edit Mouse

Glutathione S-transferase Zeta 1 (also known as maleylacetoacetate isomerase) is an enzyme that in humans is encoded by the GSTZ1 gene on chromosome 14.^[5]^[6]^[7]

This gene is a member of the glutathione S-transferase (GSTs) super-family, which encodes multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. This enzyme also plays a significant role in the catabolism of phenylalanine and tyrosine. Thus, defects in this enzyme may lead to severe metabolic disorders, including alkaptonuria, phenylketonuria and tyrosinaemia, and new discoveries may allow the enzyme to protect against certain diseases related to oxidative stress.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100577 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021033 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Board PG, Baker RT, Chelvanayagam G, Jermiin LS (Dec 1997). "Zeta, a novel class of glutathione transferases in a range of species from plants to humans". The Biochemical Journal. 328. 328 (3): 929–35. doi:10.1042/bj3280929. PMC 1219006. PMID 9396740.
^ Fernández-Cañón JM, Peñalva MA (Jan 1998). "Characterization of a fungal maleylacetoacetate isomerase gene and identification of its human homologue". The Journal of Biological Chemistry. 273 (1): 329–37. doi:10.1074/jbc.273.1.329. hdl:10261/169859. PMID 9417084.
^ ^a ^b "Entrez Gene: GSTZ1 glutathione transferase zeta 1 (maleylacetoacetate isomerase)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100577 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021033 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9396740-5] Board PG, Baker RT, Chelvanayagam G, Jermiin LS (Dec 1997). "Zeta, a novel class of glutathione transferases in a range of species from plants to humans". The Biochemical Journal. 328. 328 (3): 929–35. doi:10.1042/bj3280929. PMC 1219006. PMID 9396740.

[pmid9417084-6] Fernández-Cañón JM, Peñalva MA (Jan 1998). "Characterization of a fungal maleylacetoacetate isomerase gene and identification of its human homologue". The Journal of Biological Chemistry. 273 (1): 329–37. doi:10.1074/jbc.273.1.329. hdl:10261/169859. PMID 9417084.

[entrez-7] "Entrez Gene: GSTZ1 glutathione transferase zeta 1 (maleylacetoacetate isomerase)".

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