GT198

GT198 is a human oncogene (gene symbol PSMC3IP, alias TBPIP or Hop2)[1] located within the BRCA1 locus at chromosome 17q21.[2][3] It encodes protein product named GT198, Hop2 or TBPIP. The GT198 gene is found to be mutated with its protein overexpressed in human cancers including breast and ovarian cancers.[4][5]

GT198 acts as a DNA repair factor responsible for error-free repair of DNA double-strand breaks.[6][7][8] GT198 also controls gene regulation, including steroid hormone-mediated gene activation as a steroid hormone receptor coactivator.[3]

Similar to BRCA1, GT198 is a breast and ovarian cancer susceptibility gene with germline mutations found in a small percentage of early-onset breast and ovarian cancer families.[9]

  1. ^ PSMC3-INTERACTING PROTEIN; PSMC3IP
  2. ^ Ijichi, H.; Tanaka, T.; Nakamura, T.; Yagi, H.; Hakuba, A.; Sato, M. (2000-05-02). "Molecular cloning and characterization of a human homologue of TBPIP, a BRCA1 locus-related gene". Gene. 248 (1–2): 99–107. doi:10.1016/s0378-1119(00)00141-4. ISSN 0378-1119. PMID 10806355.
  3. ^ a b Ko, Lan; Cardona, Guemalli R.; Henrion-Caude, Alexandra; Chin, William W. (January 2002). "Identification and characterization of a tissue-specific coactivator, GT198, that interacts with the DNA-binding domains of nuclear receptors". Molecular and Cellular Biology. 22 (1): 357–369. doi:10.1128/mcb.22.1.357-369.2002. ISSN 0270-7306. PMC 134202. PMID 11739747.
  4. ^ Peng, Min; Zhang, Hao; Jaafar, Lahcen; Risinger, John I.; Huang, Shuang; Mivechi, Nahid F.; Ko, Lan (2013-11-15). "Human Ovarian Cancer Stroma Contains Luteinized Theca Cells Harboring Tumor Suppressor Gene GT198 Mutations". Journal of Biological Chemistry. 288 (46): 33387–33397. doi:10.1074/jbc.M113.485581. ISSN 0021-9258. PMC 3829185. PMID 24097974.
  5. ^ Yang, Zheqiong; Peng, Min; Cheng, Liang; Jones, Kimya; Maihle, Nita J.; Mivechi, Nahid F.; Ko, Lan (May 2016). "GT198 Expression Defines Mutant Tumor Stroma in Human Breast Cancer". The American Journal of Pathology. 186 (5): 1340–1350. doi:10.1016/j.ajpath.2016.01.006. ISSN 0002-9440. PMC 4861764. PMID 27001628.
  6. ^ Enomoto, Rima; Kinebuchi, Takashi; Sato, Makoto; Yagi, Hideshi; Shibata, Takehiko; Kurumizaka, Hitoshi; Yokoyama, Shigeyuki (2004-08-20). "Positive Role of the Mammalian TBPIP/HOP2 Protein in DMC1-mediated Homologous Pairing". Journal of Biological Chemistry. 279 (34): 35263–35272. doi:10.1074/jbc.M402481200. ISSN 0021-9258. PMID 15192114.
  7. ^ Petukhova, Galina V; Pezza, Roberto J; Vanevski, Filip; Ploquin, Mickael; Masson, Jean-Yves; Camerini-Otero, R Daniel (2005-04-17). "The Hop2 and Mnd1 proteins act in concert with Rad51 and Dmc1 in meiotic recombination". Nature Structural & Molecular Biology. 12 (5): 449–453. doi:10.1038/nsmb923. ISSN 1545-9993. PMID 15834424. S2CID 23815248.
  8. ^ Pezza, Roberto J.; Voloshin, Oleg N.; Vanevski, Filip; Camerini-Otero, R. Daniel (2007-07-15). "Hop2/Mnd1 acts on two critical steps in Dmc1-promoted homologous pairing". Genes & Development. 21 (14): 1758–1766. doi:10.1101/gad.1562907. ISSN 0890-9369. PMC 1920170. PMID 17639081.
  9. ^ Peng, Min; Bakker, Janine L.; Dicioccio, Richard A.; Gille, Johan J. P.; Zhao, Hua; Odunsi, Kunle; Sucheston, Lara; Jaafar, Lahcen; Mivechi, Nahid F. (January 2013). "Inactivating Mutations in GT198 in Familial and Early-Onset Breast and Ovarian Cancers". Genes & Cancer. 4 (1–2): 15–25. doi:10.1177/1947601913486344. ISSN 1947-6019. PMC 3743154. PMID 23946868.