GTF2H4

GTF2H4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5IY9, 5IVW, 5IY7, 5IY8, 5IY6
Identifiers
Aliases	GTF2H4, general transcription factor IIH, polypeptide 4, 52kDa, P52, TFB2, TFIIH, general transcription factor IIH subunit 4
External IDs	OMIM: 601760; MGI: 1338799; HomoloGene: 7090; GeneCards: GTF2H4; OMA:GTF2H4 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	30,914,106 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	35,984,631 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; pituitary gland; ; right hemisphere of cerebellum; ; anterior pituitary; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; body of uterus; ; tibial arteries; ; right coronary artery; ; apex of heart;
	Top expressed in
	thymus; ; otic vesicle; ; otic placode; ; spermatocyte; ; epiblast; ; saccule; ; mandibular prominence; ; abdominal wall; ; maxillary prominence; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein kinase activity; ATP-dependent activity, acting on DNA; DNA-binding transcription factor activity; DNA helicase activity; protein binding; RNA polymerase II CTD heptapeptide repeat kinase activity; double-stranded DNA binding; ATPase activator activity; RNA polymerase II general transcription initiation factor activity;
Cellular component	nucleoplasm; transcription factor TFIIH holo complex; core TFIIH complex portion of holo TFIIH complex; transcription factor TFIIH core complex; nucleus; transcription factor TFIID complex; nuclear speck;
Biological process	termination of RNA polymerase I transcription; regulation of transcription, DNA-templated; phosphorylation of RNA polymerase II C-terminal domain; transcription initiation from RNA polymerase I promoter; transcription elongation from RNA polymerase II promoter; 7-methylguanosine mRNA capping; transcription by RNA polymerase II; transcription, DNA-templated; cellular response to DNA damage stimulus; global genome nucleotide-excision repair; transcription-coupled nucleotide-excision repair; transcription initiation from RNA polymerase II promoter; nucleotide-excision repair, DNA incision; DNA repair; nucleotide-excision repair; nucleotide-excision repair, preincision complex stabilization; nucleotide-excision repair, preincision complex assembly; nucleotide-excision repair, DNA incision, 5'-to lesion; DNA duplex unwinding; positive regulation of ATP-dependent activity; nucleotide-excision repair, DNA duplex unwinding; nucleotide-excision repair, DNA incision, 3'-to lesion; transcription elongation from RNA polymerase I promoter;
	Sources:Amigo / QuickGO
Orthologs
	2968
	14885
	ENSG00000213780
	ENSMUSG00000001524
	Q92759
	O70422
	NM_001517
	NM_010364
	NP_001508
	NP_034494
	Wikidata
View/Edit Human	View/Edit Mouse

General transcription factor IIH subunit 4 is a protein that in humans is encoded by the GTF2H4 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000213780 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001524 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Marinoni JC, Roy R, Vermeulen W, Miniou P, Lutz Y, Weeda G, Seroz T, Gomez DM, Hoeijmakers JH, Egly JM (Apr 1997). "Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH". EMBO J. 16 (5): 1093–102. doi:10.1093/emboj/16.5.1093. PMC 1169708. PMID 9118947.
^ "Entrez Gene: GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000213780 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000001524 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9118947-5] Marinoni JC, Roy R, Vermeulen W, Miniou P, Lutz Y, Weeda G, Seroz T, Gomez DM, Hoeijmakers JH, Egly JM (Apr 1997). "Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH". EMBO J. 16 (5): 1093–102. doi:10.1093/emboj/16.5.1093. PMC 1169708. PMID 9118947.

[entrez-6] "Entrez Gene: GTF2H4 general transcription factor IIH, polypeptide 4, 52kDa".

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