G protein-coupled receptor kinase 2

GRK2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4PNK, 1BAK, 3CIK, 3KRW, 3KRX, 3V5W, 4MK0, 5HE1
Identifiers
Aliases	GRK2, BARK1, BETA-ARK1, ADRBK1, G protein-coupled receptor kinase 2
External IDs	OMIM: 109635; MGI: 87940; HomoloGene: 1223; GeneCards: GRK2; OMA:GRK2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.2 Start 67,266,473 bp[1] End 67,286,556 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 A|19 3.98 cM Start 4,336,029 bp[2] End 4,356,250 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte right hemisphere of cerebellum spleen right frontal lobe skin of leg skin of abdomen upper lobe of left lung right lung gallbladder Top expressed in granulocyte superior frontal gyrus tibiofemoral joint thymus dentate gyrus of hippocampal formation granule cell esophagus primary visual cortex cerebellar cortex lymph node lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity Edg-2 lysophosphatidic acid receptor binding protein kinase activity nucleotide binding G protein-coupled receptor kinase activity kinase activity protein serine/threonine kinase activity protein binding alpha-2A adrenergic receptor binding ATP binding beta-adrenergic receptor kinase activity Cellular component cytoplasm cytosol membrane plasma membrane cilium Biological process G protein-coupled acetylcholine receptor signaling pathway cardiac muscle contraction phosphorylation regulation of the force of heart contraction viral genome replication negative regulation of striated muscle contraction positive regulation of catecholamine secretion receptor internalization tachykinin receptor signaling pathway protein phosphorylation heart development peptidyl-serine phosphorylation viral entry into host cell desensitization of G protein-coupled receptor signaling pathway peptidyl-threonine phosphorylation negative regulation of the force of heart contraction by chemical signal signal transduction G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 156 110355 Ensembl ENSG00000173020 ENSMUSG00000024858 UniProt P25098 Q99MK8 RefSeq (mRNA) NM_001619 NM_001290818 NM_130863 RefSeq (protein) NP_001610 NP_001277747 NP_570933 Location (UCSC) Chr 11: 67.27 – 67.29 Mb Chr 19: 4.34 – 4.36 Mb PubMed search [3] [4]
Wikidata
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G-protein-coupled receptor kinase 2 (GRK2) is an enzyme that in humans is encoded by the ADRBK1 gene.^[5] GRK2 was initially called Beta-adrenergic receptor kinase (βARK or βARK1), and is a member of the G protein-coupled receptor kinase subfamily of the Ser/Thr protein kinases that is most highly similar to GRK3(βARK2).^[6]