Galactokinase

Galactokinase 1
Cartoon structure of a human galactokinase 1 monomer in complex with galactose (red) and an ATP analogue (orange). A magnesium ion is visible as a green sphere. (From PDB: 1WUU​)
Identifiers
SymbolGALK1
Alt. symbolsGALK
NCBI gene2584
HGNC4118
OMIM604313
RefSeqNM_000154
UniProtP51570
Other data
EC number2.7.1.6
LocusChr. 17 q23-q25
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StructuresSwiss-model
DomainsInterPro
Galactokinase 2
Identifiers
SymbolGALK2
NCBI gene2585
HGNC4119
OMIM137028
RefSeqNM_002044
UniProtQ01415
Other data
EC number2.7.1.6
LocusChr. 15 [1]
Search for
StructuresSwiss-model
DomainsInterPro

Galactokinase is an enzyme (phosphotransferase) that facilitates the phosphorylation of α-D-galactose to galactose 1-phosphate at the expense of one molecule of ATP.[1] Galactokinase catalyzes the second step of the Leloir pathway, a metabolic pathway found in most organisms for the catabolism of α-D-galactose to glucose 1-phosphate.[2] First isolated from mammalian liver, galactokinase has been studied extensively in yeast,[3][4] archaea,[5] plants,[6][7] and humans.[8][9]

  1. ^ "galactokinase". Medical Dictionary. Retrieved 2013-01-26.
  2. ^ Cite error: The named reference l was invoked but never defined (see the help page).
  3. ^ Cite error: The named reference c1 was invoked but never defined (see the help page).
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  5. ^ Hartley A, Glynn SE, Barynin V, Baker PJ, Sedelnikova SE, Verhees C, de Geus D, van der Oost J, Timson DJ, Reece RJ, Rice DW (March 2004). "Substrate specificity and mechanism from the structure of Pyrococcus furiosus galactokinase". Journal of Molecular Biology. 337 (2): 387–98. doi:10.1016/j.jmb.2004.01.043. PMID 15003454.
  6. ^ Foglietti MJ, Percheron F (1976). "[Purification and mechanism of action of a plant galactokinase]". Biochimie. 58 (5): 499–504. doi:10.1016/s0300-9084(76)80218-0. PMID 182286.
  7. ^ Dey PM (October 1983). "Galactokinase of Vicia faba seeds". European Journal of Biochemistry. 136 (1): 155–9. doi:10.1111/j.1432-1033.1983.tb07720.x. PMID 6617655.
  8. ^ Holden HM, Thoden JB, Timson DJ, Reece RJ (October 2004). "Galactokinase: structure, function and role in type II galactosemia". Cellular and Molecular Life Sciences. 61 (19–20): 2471–84. doi:10.1007/s00018-004-4160-6. PMID 15526155. S2CID 7293337.
  9. ^ Cite error: The named reference meg was invoked but never defined (see the help page).