Gamma-glutamyltransferase 1

GGT1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4GDX, 4GG2, 4Z9O, 4ZBK, 4ZC6, 4ZCG
Identifiers
Aliases	GGT1, CD224, D22S672, D22S732, GGT, GGT 1, GTG, gamma-glutamyltransferase 1, GGTD
External IDs	OMIM: 612346; MGI: 95706; HomoloGene: 68450; GeneCards: GGT1; OMA:GGT1 - orthologs
EC number	3.4.19.13
Gene location (Human)
Chr.	Chromosome 22 (human)
End	24,629,005 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	75,586,200 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; mucosa of transverse colon; ; gallbladder; ; right lung; ; body of pancreas; ; upper lobe of left lung; ; right lobe of thyroid gland; ; human kidney; ; left lobe of thyroid gland; ; gonad;
	Top expressed in
	right kidney; ; proximal tubule; ; human kidney; ; intestinal villus; ; duodenum; ; seminal vesicula; ; epithelium of small intestine; ; jejunum; ; decidua; ; efferent ductule;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; peptidase activity; protein binding; acyltransferase activity; hydrolase activity; glutathione hydrolase activity; hypoglycin A gamma-glutamyl transpeptidase activity; peptidyltransferase activity; leukotriene-C(4) hydrolase; leukotriene C4 gamma-glutamyl transferase activity;
Cellular component	integral component of membrane; membrane; plasma membrane; extracellular exosome; extracellular space;
Biological process	leukotriene metabolic process; zymogen activation; glutathione biosynthetic process; regulation of immune system process; cysteine biosynthetic process; spermatogenesis; regulation of inflammatory response; xenobiotic metabolic process; glutamate metabolic process; glutathione catabolic process; proteolysis; cellular amino acid metabolic process; glutathione metabolic process; fatty acid metabolic process; leukotriene D4 biosynthetic process; protein biosynthesis; peptide modification; response to estradiol; response to lipopolysaccharide; response to tumor necrosis factor;
	Sources:Amigo / QuickGO
Orthologs
	2678
	14598
	ENSG00000100031
	ENSMUSG00000006345
	P19440
	Q60928
NM_013430; NM_001032364; NM_001032365; NM_001288833; NM_005265;
	NM_013421
	NM_008116; NM_001305992
	NP_001275762; NP_038265; NP_038347
NP_001292921; NP_032142; NP_001366466; NP_001366467; NP_001366468;
	NP_001366469; NP_001366470
	Wikidata
View/Edit Human	View/Edit Mouse

Gamma-glutamyltransferase 1 (GGT1), also known as CD224 (Cluster of Differentiation 224), is a human gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100031 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000006345 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: GGT1 gamma-glutamyltransferase 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000100031 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000006345 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: GGT1 gamma-glutamyltransferase 1".

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