Gastrin

GAST
Identifiers
AliasesGAST, GAS, gastrin
External IDsOMIM: 137250; MGI: 104768; HomoloGene: 628; GeneCards: GAST; OMA:GAST - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000805

NM_010257

RefSeq (protein)

NP_000796

NP_034387

Location (UCSC)Chr 17: 41.71 – 41.72 MbChr 11: 100.23 – 100.23 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Gastrin
Identifiers
SymbolGastrin
PfamPF00918
InterProIPR001651
PROSITEPDOC00232
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

Gastrin is a peptide hormone that stimulates secretion of gastric acid (HCl) by the parietal cells of the stomach and aids in gastric motility. It is released by G cells in the pyloric antrum of the stomach, duodenum, and the pancreas.

Gastrin binds to cholecystokinin B receptors to stimulate the release of histamines in enterochromaffin-like cells, and it induces the insertion of K+/H+ ATPase pumps into the apical membrane of parietal cells (which in turn increases H+ release into the stomach cavity). Its release is stimulated by peptides in the lumen of the stomach.

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000184502Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017165Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.