Gatto is a surname. Notable people with the surname include:
- Anthony Gatto (born 1973), American juggler
- Carl Gatto (1937–2012), American politician
- Eddie Gatto (1916–1944), American football player
- Emanuele Gatto (born 1994), Italian footballer
- Giulia Gatto (born 1987), Italian tennis player
- Joe Gatto (artist) (1893–1965), American artist
- Joe Gatto (comedian) (born 1976), American comedian
- John Taylor Gatto (1935–2018), American educator, writer, and activist
- Laura Gatto (born in 1977), Italian long jumper
- Oscar Gatto (born 1985), Italian cyclist
- Mick Gatto (born 1955), Australian debt collector
- Mike Gatto (born 1974), American politician
- Victor Gatto (born 1947), American football player