Gemifloxacin

Gemifloxacin
Clinical data
Trade names	Factive
AHFS/Drugs.com	Monograph
MedlinePlus	a604014
License data	US DailyMed: Gemifloxacin;
Routes of; administration	By mouth
ATC code	J01MA15 (WHO) ;
Legal status
Legal status	US: WARNINGRx-only; In general: ℞ (Prescription only);
Pharmacokinetic data
Bioavailability	71%
Protein binding	60–70%
Metabolism	Limited metabolism by the liver to minor metabolites
Excretion	Feces (61%); urine (36%)
Identifiers
	IUPAC name 7-[(4Z)-3-(Aminomethyl)-4-methoxyimino-pyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo- 1,8-naphthyridine-3-carboxylic acid;
CAS Number	175463-14-6 ;
PubChem CID	9571107;
DrugBank	DB01155 ;
ChemSpider	7845573 ;
UNII	OKR68Y0E4T;
KEGG	D08012 ;
ChEBI	CHEBI:101853 ;
ChEMBL	ChEMBL430 ;
CompTox Dashboard (EPA)	DTXSID3048495 ;
Chemical and physical data
Formula	C18H20FN5O4
Molar mass	389.387 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES Fc2c(nc1N(/C=C(/C(=O)O)C(=O)c1c2)C3CC3)N4C/C(=N\OC)C(C4)CN;
	InChI InChI=1S/C18H20FN5O4/c1-28-22-14-8-23(6-9(14)5-20)17-13(19)4-11-15(25)12(18(26)27)7-24(10-2-3-10)16(11)21-17/h4,7,9-10H,2-3,5-6,8,20H2,1H3,(H,26,27)/b22-14+ ; Key:ZRCVYEYHRGVLOC-HYARGMPZSA-N ;
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Gemifloxacin mesylate, sold under the brand name Factive among others, is a broad-spectrum quinolone antibacterial agent used in the treatment of acute bacterial exacerbation of chronic bronchitis and mild-to-moderate pneumonia. It is taken by mouth. Vansen Pharma Inc. licensed the active ingredient from LG Life Sciences of Korea.^{[citation needed]}

^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.

[FDA-AllBoxedWarnings-1] "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 October 2023.

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