Generalized bullous fixed drug eruption | |
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Other names | Bullous drug eruption,[1] multilocular bullous fixed drug eruption[2]: 554 |
Drug eruption: Bullous dermatitis medicamentosa caused by sulfathiazole. | |
Specialty | Dermatology |
Generalized bullous fixed drug eruption (GBFDE) most commonly refers to a drug reaction in the erythema multiforme group.[3]: 129 These are uncommon reactions to medications, with an incidence of 0.4 to 1.2 per million person-years for toxic epidermal necrolysis and 1.2 to 6.0 per million person-years for Stevens–Johnson syndrome.[3]: 129 The primary skin lesions are large erythemas (faintly discernible even after confluence), most often irregularly distributed and of a characteristic purplish-livid color, at times with flaccid blisters.[2]: 554