Gennaro Annese (1604 – June 20, 1648) was an Italian revolutionary, who led the rebels in Naples against Spain in 1647–48.
Annese was an arquebus maker who lived near the Porta of the Carmine. He succeeded Masaniello during the Neapolitan Revolt of 1647. The following year, in April, the Spanish troops entered Naples and Annese surrendered after having been besieged in the Carmine Castle. In June, Annese was arrested and jailed in the Castel Nuovo; after a short process, he was sentenced to death and executed in the same castle.