George Frederick Sprague (September 3, 1902 – November 24, 1998) was an American geneticist, maize researcher, faculty member at Iowa State University and the University of Illinois and a researcher at the United States Department of Agriculture. He developed a genetically strong line of maize known as Iowa Stiff Stalk Synthetic. A recipient of the Wolf Prize in Agriculture, he was a fellow of the American Association for the Advancement of Science and a member of the National Academy of Sciences.