Gia Voeltz | |
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| Born | Gia Voeltz Bloomington, Indiana, United States |
| Alma mater | University of California Santa Cruz (BS) Yale University (PhD) Harvard Medical School (Postdoctoral) |
| Known for | discovering the function of the Reticulon protein family |
| Awards | Member: National Academy of Sciences 2023 Fellow: American Society for Cell Biology 2023 Investigator: Howard Hughes Medical Institute 2018 Scholar: Howard Hughes Medical Institute 2016 |
| Scientific career | |
| Fields | |
| Institutions | |
| Thesis | mRNA Stability is Regulated during Early Development by AU-rich Sequences and a Novel Poly(A) Binding Protein, ePAB (2001) |
| Doctoral advisor | Joan A. Steitz |
Gia Voeltz is an American cell biologist. She is a professor of Molecular, Cellular and Developmental Biology at the University of Colorado Boulder and a Howard Hughes Medical Institute Investigator. She is known for her research identifying the factors and unraveling the mechanisms that determine the structure and dynamics of the largest organelle in the cell: the endoplasmic reticulum. [1] [2] Her lab has produced paradigm shifting studies on organelle membrane contact sites that have revealed that most cytoplasmic organelles are not isolated entities but are instead physically tethered to an interconnected ER membrane network. [3] [4] [5]
Her research has revealed the fundamental nature of these ER contact sites in regulating the biogenesis of other organelles at positions where they are tethered and closely opposed. [6] [7] [8] [9]
- ^ Westrate LM, Lee JE, Prinz WA, Voeltz GK (January 2015). "Form follows function: the importance of endoplasmic reticulum shape". Annual Review of Biochemistry. 84: 791–811. doi:10.1146/annurev-biochem-072711-163501. PMID 25580528. S2CID 207675243.
- ^ Voeltz GK, Prinz WA, Shibata Y, Rist JM, Rapoport TA (10 February 2006). "A class of membrane proteins shaping the tubular endoplasmic reticulum". Cell. 124 (3): 573–586. doi:10.1016/j.cell.2005.11.047. PMID 16469703.
- ^ Friedman JR, Webster BM, Mastronarde DN, Verhey KJ, Voeltz GK (9 August 2010). "ER sliding dynamics and ER-mitochondrial contacts occur on acetylated microtubules". Journal of Cell Biology. 190 (3): 363–375. doi:10.1083/jcb.200911024. PMC 2922647. PMID 20696706.
- ^ Friedman JR, Dibenedetto JR, West M, Rowland AA, Voeltz GK (6 February 2013). "Endoplasmic reticulum-endosome contact increases as endosomes traffic and mature". Molecular Biology of the Cell. 24 (7): 1030–1040. doi:10.1091/mbc.E12-10-0733. PMC 3608491. PMID 23389631.
- ^ Wu H, Carvalho P, Voeltz GK (3 August 2018). "Here, there, and everywhere: The importance of ER membrane contact sites". Science. 361 (6401). doi:10.1126/science.aan5835. PMC 6568312. PMID 30072511.
- ^ Friedman JR, Lackner LL, West M, Dibenedetto JR, Nunnari J, Voeltz GK (21 October 2011). "ER tubules mark sites of mitochondrial division". Science. 334 (6954): 358–362. Bibcode:2011Sci...334..358F. doi:10.1126/science.1207385. PMC 3366560. PMID 21885730.
- ^ Rowland AA, Chitwood PJ, Phillips MJ, Voeltz GK (20 November 2014). "ER contact sites define the position and timing of endosome fission". Cell. 159 (5): 1027–1041. doi:10.1016/j.cell.2014.10.023. PMC 4634643. PMID 25416943.
- ^ Hoyer MJ, Chitwood PJ, Ebmeier CC, Striepen JF, Qi RZ, Old WM, Voeltz GK (13 September 2018). "A Novel Class of ER Membrane Proteins Regulates ER-Associated Endosome Fission". Cell. 175 (1): 254–265. doi:10.1016/j.cell.2018.08.030. PMC 6195207. PMID 30220460.
- ^ Lee JE, Cathey PI, Wu H, Parker R, Voeltz GK (31 January 2020). "Endoplasmic reticulum contact sites regulate the dynamics of membraneless organelles". Science. 367 (6477). doi:10.1126/science.aay7108. PMC 10088059. PMID 32001628.