Glial cell line-derived neurotrophic factor

GDNF
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2V5E, 3FUB, 4UX8
Identifiers
Aliases	GDNF, ATF1, ATF2, HFB1-HSCR3, glial cell derived neurotrophic factor, ATF
External IDs	OMIM: 600837; MGI: 107430; HomoloGene: 433; GeneCards: GDNF; OMA:GDNF - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5p13.2 Start 37,812,677 bp[1] End 37,840,041 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 A1 Start 7,840,327 bp[2] End 7,867,056 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in muscle of thigh tibialis anterior muscle deltoid muscle Skeletal muscle tissue of biceps brachii muscle layer of sigmoid colon gastrocnemius muscle Skeletal muscle tissue of rectus abdominis quadriceps femoris muscle gastric mucosa mucosa of ileum Top expressed in medullary collecting duct inner muscle layer muscularis mucosae renal corpuscle Hindgut Bowman's capsule epithelium of small intestine migratory enteric neural crest cell genitourinary system Gonadal ridge More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity protein binding growth factor activity signaling receptor binding chemoattractant activity involved in axon guidance Cellular component extracellular region intracellular anatomical structure extracellular space Biological process peristalsis ureteric bud development regulation of dopamine uptake involved in synaptic transmission peripheral nervous system development sympathetic nervous system development organ induction adult locomotory behavior positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis regulation of stem cell differentiation regulation of morphogenesis of a branching structure mesenchymal to epithelial transition involved in metanephros morphogenesis negative regulation of apoptotic process nervous system development positive regulation of monooxygenase activity enteric nervous system development mRNA stabilization branching involved in ureteric bud morphogenesis postganglionic parasympathetic fiber development positive regulation of dopamine secretion neural crest cell migration postsynaptic membrane organization positive regulation of cell population proliferation positive regulation of cell differentiation positive regulation of ureteric bud formation ureteric bud formation regulation of gene expression negative regulation of extrinsic apoptotic signaling pathway in absence of ligand metanephros development neuron projection development signal transduction positive regulation of transcription by RNA polymerase II MAPK cascade axon guidance negative regulation of neuron apoptotic process positive regulation of branching involved in ureteric bud morphogenesis regulation of signaling receptor activity dorsal spinal cord development embryonic organ development chemoattraction of axon commissural neuron axon guidance regulation of semaphorin-plexin signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2668 14573 Ensembl ENSG00000168621 ENSMUSG00000022144 UniProt P39905 P48540 RefSeq (mRNA) NM_000514 NM_001190468 NM_001190469 NM_001278098 NM_199231 NM_199234 NM_010275 NM_001301332 NM_001301333 NM_001301357 RefSeq (protein) NP_000505 NP_001177397 NP_001177398 NP_001265027 NP_954701 NP_001288261 NP_001288262 NP_001288286 NP_034405 Location (UCSC) Chr 5: 37.81 – 37.84 Mb Chr 15: 7.84 – 7.87 Mb PubMed search [3] [4]
Wikidata
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Glial cell line-derived neurotrophic factor (GDNF) is a protein that, in humans, is encoded by the GDNF gene.^[5] GDNF is a small protein that potently promotes the survival of many types of neurons.^[6] It signals through GFRα receptors, particularly GFRα1. It is also responsible for the determination of spermatogonia into primary spermatocytes, i.e. it is received by RET proto-oncogene (RET) and by forming gradient with SCF it divides the spermatogonia into two cells. As the result there is retention of spermatogonia and formation of spermatocyte.^{[7][full citation needed]}