Glomerular basement membrane

Glomerular basement membrane
Glomerulus; note "Glomerular basement membrane and podocytes".
Scheme of filtration barrier (blood-urine) in the kidney. A. The endothelial cells of the glomerulus; 1. pore (fenestra).
B. Glomerular basement membrane: 1. lamina rara interna 2. lamina densa 3. lamina rara externa
C. Podocytes: 1. enzymatic and structural protein 2. filtration slit 3. diaphragm
Identifiers
MeSHD050533
FMA74274
Anatomical terminology

The glomerular basement membrane of the kidney is the basal lamina layer of the glomerulus. The glomerular endothelial cells, the glomerular basement membrane, and the filtration slits between the podocytes perform the filtration function of the glomerulus, separating the blood in the capillaries from the filtrate that forms in Bowman's capsule.[1] The glomerular basement membrane is a fusion of the endothelial cell and podocyte basal laminas,[2] and is the main site of restriction of water flow.[3] Glomerular basement membrane is secreted and maintained by podocyte cells.

  1. ^ Jarad, G.; Miner, J. H. (2009). "Update on the glomerular filtration barrier". Current Opinion in Nephrology and Hypertension. 18 (3): 226–232. doi:10.1097/mnh.0b013e3283296044. PMC 2895306. PMID 19374010.
  2. ^ Nosek, Thomas M. "Section 7/7ch04/7ch04p07". Essentials of Human Physiology. Archived from the original on 2016-03-24. - "Basement Membrane"
  3. ^ Lote, Christopher J. Principles of Renal Physiology, 5th edition. Springer. p. 35.