Glucokinase regulatory protein

glucokinase (hexokinase 4) regulator
Identifiers
SymbolGCKR
NCBI gene2646
HGNC4196
OMIM600842
RefSeqNM_001486
UniProtQ14397
Other data
LocusChr. 2 p23
Search for
StructuresSwiss-model
DomainsInterPro

The glucokinase regulatory protein (GKRP) also known as glucokinase (hexokinase 4) regulator (GCKR) is a protein produced in hepatocytes (liver cells). GKRP binds and moves glucokinase (GK), thereby controlling both activity and intracellular location[1][2] of this key enzyme of glucose metabolism.[3]

GKRP is a 68 kD protein of 626 amino acids. It is coded for by a 19 exon gene, GCKR, on the short arm of chromosome 2 (2p23). GKRP was discovered by Emile van Schaftingen and reported in 1989[4]

  1. ^ Van Schaftingen E (September 1994). "Short-term regulation of glucokinase". Diabetologia. 37 (Suppl 2): S43-7. doi:10.1007/bf00400825. PMID 7821739.
  2. ^ de la Iglesia N, Veiga-da-Cunha M, Van Schaftingen E, Guinovart JJ, Ferrer JC (August 1999). "Glucokinase regulatory protein is essential for the proper subcellular localisation of liver glucokinase". FEBS Letters. 456 (2): 332–8. doi:10.1016/S0014-5793(99)00971-0. PMID 10456334. S2CID 11923216.
  3. ^ Iynedjian PB (January 2009). "Molecular physiology of mammalian glucokinase". Cellular and Molecular Life Sciences. 66 (1): 27–42. doi:10.1007/s00018-008-8322-9. PMC 2780631. PMID 18726182.
  4. ^ Van Schaftingen E (January 1989). "A protein from rat liver confers to glucokinase the property of being antagonistically regulated by fructose 6-phosphate and fructose 1-phosphate". European Journal of Biochemistry. 179 (1): 179–84. doi:10.1111/j.1432-1033.1989.tb14538.x. PMID 2917560.