Glutaminase

Not to be confused with Transglutaminase.
glutaminase
Crystallographic structure of dimeric protein-glutaminase from Chryseobacterium proteolyticum.[1]
Identifiers
EC no.3.5.1.2
CAS no.9001-47-2
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
Search
PMCarticles
PubMedarticles
NCBIproteins
Glutaminase
probable glutaminase from bacillus subtilis complexed with 6-diazo-5-oxo-ʟ-norleucine
Identifiers
SymbolGlutaminase
PfamPF04960
Pfam clanCL0013
InterProIPR015868
SCOP21mki / SCOPe / SUPFAM
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

Glutaminase (EC 3.5.1.2, glutaminase I, L-glutaminase, glutamine aminohydrolase) is an amidohydrolase enzyme that generates glutamate from glutamine. Glutaminase has tissue-specific isoenzymes. Glutaminase has an important role in glial cells.

Glutaminase catalyzes the following reaction:

Glutamine + H2O → glutamate + NH+4
  1. ^ PDB: 3A56​; Hashizume R, Mizutani K, Takahashi N, Matsubara H, Matsunaga A, Yamaguchi S, Mikami B (2010). Crystal structure of protein-glutaminase. doi:10.2210/pdb3a56/pdb.