Glycine receptor, alpha 1

GLRA1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1MOT, 1VRY, 2M6B, 2M6I, 4X5T
Identifiers
Aliases	GLRA1, HKPX1, STHE, Glycine receptor, alpha 1, glycine receptor alpha 1
External IDs	OMIM: 138491; MGI: 95747; HomoloGene: 20083; GeneCards: GLRA1; OMA:GLRA1 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	151,924,851 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	55,499,024 bp
RNA expression pattern
	Top expressed in
	islet of Langerhans; ; testicle; ; hypothalamus; ; substantia nigra; ; C1 segment; ; ganglionic eminence; ; cerebellum; ; cerebellar cortex; ; cerebellar hemisphere; ; gonad;
	Top expressed in
	medial vestibular nucleus; ; lumbar subsegment of spinal cord; ; ventromedial nucleus; ; pontine nuclei; ; anterior horn of spinal cord; ; dorsal tegmental nucleus; ; facial motor nucleus; ; deep cerebellar nuclei; ; superior colliculus; ; lateral hypothalamus;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	zinc ion binding; glycine binding; metal ion binding; transmitter-gated ion channel activity; extracellularly glycine-gated chloride channel activity; protein binding; extracellularly glycine-gated ion channel activity; taurine binding; chloride channel activity; extracellular ligand-gated ion channel activity; ion channel activity; identical protein binding; transmembrane signaling receptor activity; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential;
Cellular component	integral component of membrane; perikaryon; postsynaptic membrane; cell projection; intracellular membrane-bounded organelle; membrane; plasma membrane; synapse; integral component of plasma membrane; inhibitory synapse; intracellular anatomical structure; chloride channel complex; cell junction; dendrite; endoplasmic reticulum; external side of plasma membrane; soma; neuron projection; calyx of Held; glycinergic synapse; integral component of presynaptic membrane; integral component of postsynaptic specialization membrane;
Biological process	inhibitory postsynaptic potential; muscle contraction; startle response; neuromuscular process controlling posture; cellular response to ethanol; protein heterooligomerization; regulation of respiratory gaseous exchange; regulation of membrane potential; ion transport; anion transport; cellular response to zinc ion; regulation of respiratory gaseous exchange by nervous system process; acrosome reaction; positive regulation of acrosome reaction; neuromuscular process; cellular response to amino acid stimulus; synaptic transmission, glycinergic; action potential; chloride transport; righting reflex; neuropeptide signaling pathway; protein homooligomerization; negative regulation of transmission of nerve impulse; visual perception; adult walking behavior; chloride transmembrane transport; response to alcohol; excitatory postsynaptic potential; chemical synaptic transmission; ion transmembrane transport; signal transduction; response to amino acid; nervous system process;
	Sources:Amigo / QuickGO
Orthologs
	2741
	14654
	ENSG00000145888
	ENSMUSG00000000263
	P23415
	Q64018
	NM_000171; NM_001146040; NM_001292000
	NM_001290821; NM_020492
	NP_000162; NP_001139512; NP_001278929
	NP_001277750; NP_065238
	Wikidata
View/Edit Human	View/Edit Mouse

Glycine receptor subunit alpha-1 is a protein that in humans is encoded by the GLRA1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000145888 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000000263 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ryan SG, Sherman SL, Terry JC, Sparkes RS, Torres MC, Mackey RW (Sep 1992). "Startle disease, or hyperekplexia: response to clonazepam and assignment of the gene (STHE) to chromosome 5q by linkage analysis". Ann Neurol. 31 (6): 663–668. doi:10.1002/ana.410310615. PMID 1355335. S2CID 28879043.
^ Shiang R, Ryan SG, Zhu YZ, Hahn AF, O'Connell P, Wasmuth JJ (Mar 1994). "Mutations in the alpha 1 subunit of the inhibitory glycine receptor cause the dominant neurologic disorder, hyperekplexia". Nat Genet. 5 (4): 351–358. doi:10.1038/ng1293-351. PMID 8298642. S2CID 21410824.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000145888 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000000263 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1355335-5] Ryan SG, Sherman SL, Terry JC, Sparkes RS, Torres MC, Mackey RW (Sep 1992). "Startle disease, or hyperekplexia: response to clonazepam and assignment of the gene (STHE) to chromosome 5q by linkage analysis". Ann Neurol. 31 (6): 663–668. doi:10.1002/ana.410310615. PMID 1355335. S2CID 28879043.

[pmid8298642-6] Shiang R, Ryan SG, Zhu YZ, Hahn AF, O'Connell P, Wasmuth JJ (Mar 1994). "Mutations in the alpha 1 subunit of the inhibitory glycine receptor cause the dominant neurologic disorder, hyperekplexia". Nat Genet. 5 (4): 351–358. doi:10.1038/ng1293-351. PMID 8298642. S2CID 21410824.

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