The granulocyte-macrophage colony-stimulating factor receptor, also known as CD116 (Cluster of Differentiation 116), is a receptor for granulocyte-macrophage colony-stimulating factor, which stimulates the production of white blood cells.[5] In contrast to M-CSF and G-CSF which are lineage specific, GM-CSF and its receptor play a role in earlier stages of development. The receptor is primarily located on neutrophils, eosinophils and monocytes/macrophages, it is also on CD34+ progenitor cells (myeloblasts) and precursors for erythroid and megakaryocytic lineages, but only in the beginning of their development.[5][6]
It is associated with Surfactant metabolism dysfunction type 4.
- ^ a b c GRCh38: Ensembl release 89: ENSG00000198223 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059326 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b Nicola NA, Metcalf D (August 1985). "Binding of 125I-labeled granulocyte colony-stimulating factor to normal murine hemopoietic cells". Journal of Cellular Physiology. 124 (2): 313–321. doi:10.1002/jcp.1041240222. PMID 3876343. S2CID 3054917.
- ^ Barreda DR, Hanington PC, Belosevic M (May 2004). "Regulation of myeloid development and function by colony stimulating factors". Developmental and Comparative Immunology. 28 (5): 509–554. doi:10.1016/j.dci.2003.09.010. PMID 15062647.