Granulocyte colony-stimulating factor

CSF3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesCSF3, C17orf33, CSF3OS, GCSF, colony stimulating factor 3
External IDsOMIM: 138970; MGI: 1339751; HomoloGene: 7677; GeneCards: CSF3; OMA:CSF3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000759
NM_001178147
NM_172219
NM_172220

NM_009971

RefSeq (protein)

NP_000750
NP_001171618
NP_757373
NP_757374

NP_034101

Location (UCSC)Chr 17: 40.02 – 40.02 MbChr 11: 98.59 – 98.59 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Granulocyte colony-stimulating factor (G-CSF or GCSF), also known as colony-stimulating factor 3 (CSF 3), is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream.[5][6]

Functionally, it is a cytokine and hormone, a type of colony-stimulating factor, and is produced by a number of different tissues. The pharmaceutical analogs of naturally occurring G-CSF are called filgrastim and lenograstim.

G-CSF also stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils.

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000108342Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000038067Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Deotare U, Al-Dawsari G, Couban S, Lipton JH (September 2015). "G-CSF-primed bone marrow as a source of stem cells for allografting: revisiting the concept". Bone Marrow Transplantation. 50 (9): 1150–1156. doi:10.1038/bmt.2015.80. PMID 25915812. S2CID 20774089.
  6. ^ Tay J, Levesque JP, Winkler IG (February 2017). "Cellular players of hematopoietic stem cell mobilization in the bone marrow niche". International Journal of Hematology. 105 (2): 129–140. doi:10.1007/s12185-016-2162-4. PMID 27943116.