Granuloma

"Granulomatous" and "Granulomatous reactions" redirect here. For the adverse reaction, see interstitial granulomatous drug reaction. Not to be confused with Granulation tissue.
Granuloma
Picture of a granuloma (without necrosis) as seen through a microscope on a glass slide: The tissue on the slide is stained with two standard dyes (hematoxylin: blue, eosin: pink) to make it visible. The granuloma in this picture was found in a lymph node of a patient with a Mycobacterium avium infection.
SpecialtyPathology

A granuloma is an aggregation of macrophages (along with other cells) that forms in response to chronic inflammation. This occurs when the immune system attempts to isolate foreign substances that it is otherwise unable to eliminate.[1] Such substances include infectious organisms including bacteria and fungi, as well as other materials such as foreign objects, keratin, and suture fragments.[2][3][4][5]

  1. ^ Williams O, Fatima S (5 April 2020). "Granuloma". StatPearls. Treasure Island: StatPearls Publishing. PMID 32119473. Archived from the original on 23 May 2021. Retrieved 2 December 2020.
  2. ^ Cite error: The named reference Muk7 was invoked but never defined (see the help page).
  3. ^ Woodard BH, Rosenberg SI, Farnham R, Adams DO (1982). "Incidence and nature of primary granulomatous inflammation in surgically removed material". American Journal of Surgical Pathology. 6 (2): 119–129. doi:10.1097/00000478-198203000-00004. PMID 7102892. S2CID 12907076.
  4. ^ Hunter DC, Logie JR (1988). "Suture granuloma". British Journal of Surgery. 75 (11): 1149–1150. doi:10.1002/bjs.1800751140. PMID 3208057. S2CID 12804852.
  5. ^ Chen KT, Kostich ND, Rosai J (1978). "Peritoneal foreign body granulomas to keratin in uterine adenocanthoma". Archives of Pathology and Laboratory Medicine. 102 (4): 174–177. PMID 580709.