Granuloma inguinale

Not to be confused with Granuloma annulare.
This article is about the ulcerative disease caused by Klebsiella granulomatis. For the sexually transmitted infection caused by certain types of chlamydia, see Lymphogranuloma venereum.
Granuloma inguinale
Other namesDonovanosis
Donovanosis
SpecialtyInfectious diseases, dermatology Edit this on Wikidata

Granuloma inguinale is a bacterial disease caused by Klebsiella granulomatis (formerly known as Calymmatobacterium granulomatis)[1] characterized by genital ulcers.[2] It is endemic in many less-developed regions. It is also known as donovanosis,[3] granuloma genitoinguinale,[3] granuloma inguinale tropicum,[3] granuloma venereum,[4] granuloma venereum genitoinguinale,[3] lupoid form of groin ulceration,[3] serpiginous ulceration of the groin,[3] ulcerating granuloma of the pudendum,[3] and ulcerating sclerosing granuloma. Oral manifestations are also notably seen. The lesions of oral cavity are usually secondary to active genital lesions.

The disease often goes untreated because of the scarcity of medical treatment in the countries in which it is found. In addition, the painless genital ulcers can be mistaken for syphilis.[5] The ulcers ultimately progress to destruction of internal and external tissue, with extensive leakage of mucus and blood from the highly vascular lesions. The destructive nature of donovanosis also increases the risk of superinfection by other pathogenic microbes.

  1. ^ O’Farrell, N (2002). "Donovanosis". Sexually Transmitted Infections. 78 (6): 452–7. doi:10.1136/sti.78.6.452. PMC 1758360. PMID 12473810.
  2. ^ Wilson, Janet D.; Anderson, Jane (2020). "37. Sexually transmitted infections and human immunodeficiency virus". In Feather, Adam; Randall, David; Waterhouse, Mona (eds.). Kumar and Clark's Clinical Medicine (10th ed.). Elsevier. p. 1425. ISBN 978-0-7020-7870-5.
  3. ^ a b c d e f g Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 978-1-4160-2999-1.
  4. ^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. p. 275. ISBN 978-0-7216-2921-6.
  5. ^ Murray, Patrick R; Rosenthal, Ken S; Pfaller, Michael A (2005). Medical Microbiology (5th ed.). Philadelphia: Elsevier Mosby. p. 336. ISBN 978-0-323-03303-9.