Granulopoiesis

Diagram of human haematopoiesis, showing all types of granulocyte precursors.

Granulopoiesis (or granulocytopoiesis) is a part of haematopoiesis, that leads to the production of granulocytes. A granulocyte, also referred to as a polymorphonuclear leukocyte (PMN), is a type of white blood cell that has multi lobed nuclei, usually containing three lobes, and has a significant amount of cytoplasmic granules within the cell.[1] Granulopoiesis takes place in the bone marrow.[2] It leads to the production of three types of mature granulocytes: neutrophils (most abundant, making up to 60% of all white blood cells), eosinophils (up to 4%) and basophils (up to 1%).[3]

  1. ^ Cowland JB, Borregaard N (September 2016). "Granulopoiesis and granules of human neutrophils". Immunological Reviews. 273 (1): 11–28. doi:10.1111/imr.12440. PMID 27558325. S2CID 28294497.
  2. ^ Morrison SJ, Scadden DT (January 2014). "The bone marrow niche for haematopoietic stem cells". Nature. 505 (7483): 327–34. Bibcode:2014Natur.505..327M. doi:10.1038/nature12984. PMC 4514480. PMID 24429631.
  3. ^ Blumenreich MS (1990). "The White Blood Cell and Differential Count". In Walker HK, Hall WD, Hurst JW (eds.). Clinical Methods: The History, Physical, and Laboratory Examinations (3rd ed.). Butterworths. ISBN 978-0-409-90077-4. PMID 21250104. Retrieved 2020-01-23.