Great Debate may refer to
- The Great Debate, also called the Samye Debate, the Council of Lhasa or the Council of Samye, a decisive debate in Tibetan Buddhism from 792 to 794
- The Great Debates of 1858, the Lincoln–Douglas debates
- Great Debates (international relations), a series of disagreements between international relations scholars
- The Great Debate, a national discussion in the United Kingdom about state education, touched off by a 1976 speech by Prime Minister James Callaghan
- Great Debate (Cuba), a debate in Cuba about how to transform the economy from 1962-1965.