Great Marlborough Street is a thoroughfare in Soho, Central London. It runs east of Regent Street past Carnaby Street towards Noel Street.
Originally part of the Millfield estate south of Tyburn Road (now Oxford Street), the street was named after John Churchill, 1st Duke of Marlborough, and was laid out around 1704. It was a fashionable address in the 18th century, but its character changed to commercial and retail use by the end of the 19th. Most of the street's original buildings have since been demolished. Great Marlborough Street has had an association with the law since the late-18th century; Marlborough Street Magistrates Court subsequently became one of the most important magistrates courts in London. The department store Liberty is on the corner of Great Marlborough Street with Regent Street and sports a Mock Tudor facade.