Grigor Artsruni (also spelled as Krikor Ardzruni, Armenian: Գրիգոր Արծրունի; 27 February 1845 – 19 December 1892) was an Armenian journalist, critic, writer and public activist. In 1872, he began publishing the newspaper Mshak and remained its editor and manager until his death.
He studied at the universities of Moscow and Saint Petersburg, then studied Armenian at the Mekhitarists' centers in Europe (Vienna and San Lazzaro, Venice). He graduated from Heidelberg University in 1869, receiving the degree of Doctor of Political Economy and Philosophy. In 1872, he established and edited Mshak ('Cultivator' or 'Toiler'), the basis of Armenian liberalism. Artsruni believed in the necessity of development of capitalism in Armenia and supported the idea of armed resistance as a solution for the Armenian question. Artsruni was a mentor to the Armenian writer Raffi (1835–1888).