In mathematics, in the field of homological algebra, the Grothendieck spectral sequence, introduced by Alexander Grothendieck in his Tôhoku paper, is a spectral sequence that computes the derived functors of the composition of two functors , from knowledge of the derived functors of and . Many spectral sequences in algebraic geometry are instances of the Grothendieck spectral sequence, for example the Leray spectral sequence.