Growth-hormone-releasing hormone receptor

GHRHR
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2XDG
Identifiers
Aliases	GHRHR, GHRFR, GRFR, IGHD1B, growth hormone releasing hormone receptor, IGHD4
External IDs	OMIM: 139191; MGI: 95710; HomoloGene: 640; GeneCards: GHRHR; OMA:GHRHR - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p14.3 Start 30,938,669 bp[1] End 30,993,254 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 B3|6 27.38 cM Start 55,353,280 bp[2] End 55,365,515 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pituitary gland anterior pituitary oocyte secondary oocyte hypothalamus cingulate gyrus anterior cingulate cortex amygdala Descending thoracic aorta nucleus accumbens Top expressed in pituitary gland anterior pituitary choroid plexus of fourth ventricle entorhinal cortex CA3 field soleus muscle proximal tubule right kidney yolk sac tibialis anterior muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function G protein-coupled receptor activity growth factor binding signal transducer activity peptide hormone binding protein binding growth hormone-releasing hormone receptor activity transmembrane signaling receptor activity G protein-coupled peptide receptor activity Cellular component cytoplasm integral component of membrane membrane nuclear matrix plasma membrane secretory granule cell surface nuclear inner membrane sarcolemma nuclear outer membrane Biological process adenylate cyclase-activating G protein-coupled receptor signaling pathway determination of adult lifespan adenylate cyclase-modulating G protein-coupled receptor signaling pathway response to glucocorticoid cell maturation adenohypophysis development water homeostasis activation of adenylate cyclase activity response to estrogen mammary gland development response to insulin positive regulation of circadian sleep/wake cycle, non-REM sleep cell surface receptor signaling pathway regulation of insulin-like growth factor receptor signaling pathway positive regulation of insulin-like growth factor receptor signaling pathway growth hormone secretion positive regulation of growth hormone secretion positive regulation of cell population proliferation positive regulation of multicellular organism growth cellular response to insulin stimulus somatotropin secreting cell development regulation of protein metabolic process lactation regulation of intracellular steroid hormone receptor signaling pathway hormone metabolic process positive regulation of hormone secretion cAMP-mediated signaling cellular response to glucose stimulus signal transduction multicellular organismal reproductive process G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2692 14602 Ensembl ENSG00000106128 ENSMUSG00000004654 UniProt Q02643 P32082 RefSeq (mRNA) NM_000823 NM_001009824 NM_001003685 RefSeq (protein) NP_000814 NP_001003685 Location (UCSC) Chr 7: 30.94 – 30.99 Mb Chr 6: 55.35 – 55.37 Mb PubMed search [3] [4]
Wikidata
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The growth-hormone-releasing hormone receptor (GHRHR) is a G-protein-coupled receptor that binds growth hormone-releasing hormone. The GHRHR activates a Gs protein that causes a cascade of cAMP via adenylate cyclase.^[5] GHRHR is distinct from the growth hormone secretagogue receptor (also known as the ghrelin receptor), where growth hormone releasing peptides act to release growth hormone.