Guanethidine

Guanethidine
Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
MedlinePlus	a600027
ATC code	C02CC02 (WHO) S01EX01 (WHO);
Pharmacokinetic data
Elimination half-life	1.5 days
Identifiers
	IUPAC name 2-[2-(azocan-1-yl)ethyl]guanidine;
CAS Number	645-43-2 ;
PubChem CID	3518;
IUPHAR/BPS	7194;
DrugBank	DB01170 ;
ChemSpider	3398 ;
UNII	5UBY8Y002G;
KEGG	D08030 ;
ChEBI	CHEBI:5557 ;
ChEMBL	ChEMBL765 ;
CompTox Dashboard (EPA)	DTXSID5023116 ;
ECHA InfoCard	100.000.220
Chemical and physical data
Formula	C10H22N4
Molar mass	198.314 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES N(=C(\N)N)\CCN1CCCCCCC1;
	InChI InChI=1S/C10H22N4/c11-10(12)13-6-9-14-7-4-2-1-3-5-8-14/h1-9H2,(H4,11,12,13) ; Key:ACGDKVXYNVEAGU-UHFFFAOYSA-N ;
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Guanethidine is an antihypertensive drug that reduces the release of catecholamines, such as norepinephrine. Guanethidine is transported across the sympathetic nerve membrane by the same mechanism that transports norepinephrine itself (NET, uptake 1), and uptake is essential for the drug's action. Once guanethidine has entered the nerve, it is concentrated in transmitter vesicles, where it replaces norepinephrine. It may also inhibit the release of granules by decreasing norepinephrine.