Guanidinium thiocyanate

Guanidinium thiocyanate
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard 100.008.922 Edit this at Wikidata
EC Number
  • 209-812-1
UNII
  • InChI=1S/CH5N3.CHNS/c2-1(3)4;2-1-3/h(H5,2,3,4);3H checkY
    Key: ZJYYHGLJYGJLLN-UHFFFAOYSA-N checkY
  • InChI=1/CH5N3.CHNS/c2-1(3)4;2-1-3/h(H5,2,3,4);3H
    Key: ZJYYHGLJYGJLLN-UHFFFAOYAS
  • N#CS.[N@H]=C(N)N
Properties
C2H6N4S
Molar mass 118.16 g·mol−1
Hazards
GHS labelling:
GHS05: CorrosiveGHS07: Exclamation mark
Danger
H302, H312, H314, H332, H412
P260, P261, P264, P270, P271, P273, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P312, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P363, P405, P501
Safety data sheet (SDS) External MSDS
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
checkY verify (what is checkY☒N ?)

Guanidinium thiocyanate (GTC) or guanidinium isothiocyanate (GITC) is a chemical compound used as a general protein denaturant, being a chaotropic agent, although it is most commonly used as a nucleic acid protector in the extraction of DNA and RNA from cells.[1]

GITC may also be recognized as guanidine thiocyanate. This is because guanidinium is the conjugate acid of guanidine and is called the guanidinium cation, [CH6N3]+.

  1. ^ Mason, P. E.; Neilson, G. W.; Dempsey, C. E.; Barnes, A. C.; Cruickshank, J. M. (2003). "The hydration structure of guanidinium and thiocyanate ions: Implications for protein stability in aqueous solution". Proceedings of the National Academy of Sciences. 100 (8): 4557–4561. Bibcode:2003PNAS..100.4557M. doi:10.1073/pnas.0735920100. PMC 404697. PMID 12684536.