Guillaume Durand (died 1328 or 1330) was a French clergyman, a nephew of a more famous Guillaume Durand, nicknamed "The Speculator".
Like his uncle, he was a canonist, was rector of the University of Toulouse and succeeded his uncle as Bishop of Mende. Pope John XXII and Charles IV of France sent him on an embassy to the Sultan Orhan (1326–1360) at Brusa, to obtain more favourable conditions for the Latins in Syria. He died on the way back, in Cyprus (1328 or 1330).