Guyandotte is a historic neighborhood in the city of Huntington, West Virginia, that previously existed as a separate town before annexation was completed by the latter. The neighborhood is home to many historic properties, and was first settled by natives of France at the end of the eighteenth century. Guyandotte was already a thriving town when the state of West Virginia was formed from part of Virginia. Located at the confluence of the Guyandotte River and the Ohio River, it was already a regional trade center with several industries of its own when the Chesapeake and Ohio Railway (C&O) reached its western terminus nearby just across the Guyandotte River in 1873. This event was soon followed by the formation and quick development of the present city of Huntington which was named in honor of the C&O Railway's founder and then principal owner Collis P. Huntington.