H2AFV

H2AZ2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3WAA
Identifiers
Aliases	H2AZ2, H2A.Z-2, H2AV, H2A histone family member V, H2A.Z variant histone 2, H2AFV
External IDs	MGI: 1924855; HomoloGene: 83271; GeneCards: H2AZ2; OMA:H2AZ2 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	44,848,087 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	6,394,443 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; optic nerve; ; rectum; ; mucosa of transverse colon; ; right ventricle; ; epithelium of colon; ; endothelial cell; ; left ventricle; ; Achilles tendon;
	Top expressed in
	Ileal epithelium; ; medial ganglionic eminence; ; ventricular zone; ; maxillary prominence; ; mandibular prominence; ; endocardial cushion; ; abdominal wall; ; somite; ; migratory enteric neural crest cell; ; thymus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein heterodimerization activity; molecular function;
Cellular component	nucleosome; extracellular exosome; nucleus; chromosome;
Biological process	chromatin organization; biological process;
	Sources:Amigo / QuickGO
Orthologs
	94239
	77605
	ENSG00000105968
	ENSMUSG00000041126
	Q71UI9
	Q3THW5
	NM_201517; NM_012412; NM_138635; NM_201436; NM_201516
	NM_029938; NM_001347064
	NP_036544; NP_619541; NP_958844; NP_958924; NP_958925
	NP_001333993; NP_084214
	Wikidata
View/Edit Human	View/Edit Mouse

Histone H2A.V is a protein that in humans is encoded by the H2AFV gene.^[5]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a member of the histone H2A family. Several transcripts have been identified for this gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105968 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041126 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: H2AFV H2A histone family, member V".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105968 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041126 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: H2AFV H2A histone family, member V".

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