H3K27me3

H3K27me3 is an epigenetic modification to the DNA packaging protein histone H3. It is a mark that indicates the tri-methylation of lysine 27 on histone H3 protein.

This tri-methylation is associated with the downregulation of nearby genes via the formation of heterochromatic regions.^[1]

^ Ferrari KJ, Scelfo A, Jammula S, Cuomo A, Barozzi I, Stützer A, Fischle W, Bonaldi T, Pasini D (January 2014). "Polycomb-dependent H3K27me1 and H3K27me2 regulate active transcription and enhancer fidelity". Molecular Cell. 53 (1): 49–62. doi:10.1016/j.molcel.2013.10.030. hdl:11858/00-001M-0000-0015-367D-4. PMID 24289921.

[1] Ferrari KJ, Scelfo A, Jammula S, Cuomo A, Barozzi I, Stützer A, Fischle W, Bonaldi T, Pasini D (January 2014). "Polycomb-dependent H3K27me1 and H3K27me2 regulate active transcription and enhancer fidelity". Molecular Cell. 53 (1): 49–62. doi:10.1016/j.molcel.2013.10.030. hdl:11858/00-001M-0000-0015-367D-4. PMID 24289921.

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