HAS3

HAS3
Identifiers
Aliases	HAS3, hyaluronan synthase 3
External IDs	OMIM: 602428; MGI: 109599; HomoloGene: 68461; GeneCards: HAS3; OMA:HAS3 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	69,118,719 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	107,611,198 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; cartilage tissue; ; mucosa of esophagus; ; urinary bladder; ; tendon of biceps brachii; ; mucosa of transverse colon; ; vagina; ; testicle; ; olfactory zone of nasal mucosa; ; skin of abdomen;
	Top expressed in
	inner enamel epithelium; ; stratum intermedium; ; hair follicle; ; secondary oocyte; ; hair; ; primary oocyte; ; mandibular molars; ; zygote; ; tail of embryo; ; lip;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; glycosyltransferase activity; hyaluronan synthase activity; protein binding; identical protein binding;
Cellular component	cytoplasm; integral component of membrane; plasma membrane; hyaluranon cable; integral component of plasma membrane; membrane;
Biological process	positive regulation of transcription, DNA-templated; cell adhesion; hyaluronan biosynthetic process; extracellular matrix assembly; positive regulation of hyaluranon cable assembly; extracellular polysaccharide biosynthetic process; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	3038
	15118
	ENSG00000103044
	ENSMUSG00000031910
	O00219
	O08650
	NM_001199280; NM_005329; NM_138612
	NM_008217; NM_001331048
	NP_001186209; NP_005320; NP_619515
	NP_001317977; NP_032243
	Wikidata
View/Edit Human	View/Edit Mouse

Hyaluronan synthase 3 is an enzyme that in humans is encoded by the HAS3 gene.^[5]^[6]^[7]

The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Two transcript variants encoding different isoforms have been found for this gene.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000103044 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031910 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Spicer AP, Seldin MF, Olsen AS, Brown N, Wells DE, Doggett NA, Itano N, Kimata K, Inazawa J, McDonald JA (Jul 1997). "Chromosomal localization of the human and mouse hyaluronan synthase genes". Genomics. 41 (3): 493–7. doi:10.1006/geno.1997.4696. PMID 9169154.
^ Spicer AP, Olson JS, McDonald JA (May 1997). "Molecular cloning and characterization of a cDNA encoding the third putative mammalian hyaluronan synthase". J Biol Chem. 272 (14): 8957–61. doi:10.1074/jbc.272.14.8957. PMID 9083017.
^ ^a ^b "Entrez Gene: HAS3 hyaluronan synthase 3".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000103044 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031910 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9169154-5] Spicer AP, Seldin MF, Olsen AS, Brown N, Wells DE, Doggett NA, Itano N, Kimata K, Inazawa J, McDonald JA (Jul 1997). "Chromosomal localization of the human and mouse hyaluronan synthase genes". Genomics. 41 (3): 493–7. doi:10.1006/geno.1997.4696. PMID 9169154.

[pmid9083017-6] Spicer AP, Olson JS, McDonald JA (May 1997). "Molecular cloning and characterization of a cDNA encoding the third putative mammalian hyaluronan synthase". J Biol Chem. 272 (14): 8957–61. doi:10.1074/jbc.272.14.8957. PMID 9083017.

[entrez-7] "Entrez Gene: HAS3 hyaluronan synthase 3".

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