HAVCR1

HAVCR1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesHAVCR1, HAVCR, HAVCR-1, KIM-1, KIM1, TIM, TIM-1, TIM1, TIMD-1, TIMD1, CD365, hepatitis A virus cellular receptor 1
External IDsOMIM: 606518; MGI: 2159680; HomoloGene: 134424; GeneCards: HAVCR1; OMA:HAVCR1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001099414
NM_001173393
NM_001308156
NM_012206

NM_001166631
NM_001166632
NM_134248

RefSeq (protein)

NP_001166864
NP_001295085
NP_036338

NP_001160103
NP_001160104
NP_599009

Location (UCSC)Chr 5: 157.03 – 157.06 MbChr 11: 46.63 – 46.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Hepatitis A virus cellular receptor 1 (HAVcr-1) also known as T-cell immunoglobulin and mucin domain 1 (TIM-1) is a protein that in humans is encoded by the HAVCR1 gene.[5][6][7]

It is also known as KIM-1 Kidney Injury Molecule -1, which is a type 1 transmembrane protein the most highly upregulated in injured kidneys by various types of insults.[8] Its upregulation during renal injury has been found in the kidneys of the vertebrates such as Zebrafish and humans.

The hepatitis A virus cellular receptor 1 (HAVCR1/TIM-1), is a member of the TIM (T cell transmembrane, immunoglobulin, and mucin) gene family, which plays critical roles in regulating immune cell activity especially regarding the host response to viral infection. TIM-1 is also involved in allergic response, asthma, and transplant tolerance.

The TIM gene family was first cloned from the mouse model of asthma in 2001.[6] Subsequently, it was demonstrated that members of the TIM gene family including TIM-1 participate in host immune response. The mouse TIM gene family contains eight members (TIM-1-8) while only three TIM genes (TIM-1, TIM-3, and TIM-4) have been identified in humans.

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000113249Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040405Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Feigelstock D, Thompson P, Mattoo P, Zhang Y, Kaplan GG (Aug 1998). "The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor". Journal of Virology. 72 (8): 6621–6628. doi:10.1128/JVI.72.8.6621-6628.1998. PMC 109848. PMID 9658108.
  6. ^ a b McIntire JJ, Umetsu SE, Akbari O, Potter M, Kuchroo VK, Barsh GS, Freeman GJ, Umetsu DT, DeKruyff RH (November 2001). "Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family". Nature Immunology. 2 (12): 1109–1116. doi:10.1038/ni739. PMID 11725301. S2CID 7243788.
  7. ^ "Entrez Gene: HAVCR1 hepatitis A virus cellular receptor 1".
  8. ^ Han WK, Bailly V, Abichandani R, Thadhani R, Bonventre JV (July 2002). "Kidney Injury Molecule-1 (KIM-1): A novel biomarker for human renal proximal tubule injury". Kidney International. 62 (1): 237–244. doi:10.1046/j.1523-1755.2002.00433.x. ISSN 0085-2538. PMID 12081583.