HCK

HCK
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1AD5, 1BU1, 1QCF, 2C0I, 2C0O, 2C0T, 2HCK, 2HK5, 2OI3, 2OJ2, 3HCK, 3NHN, 3RBB, 3REA, 3REB, 3VRY, 3VRZ, 3VS0, 3VS1, 3VS2, 3VS3, 3VS4, 3VS5, 3VS6, 3VS7, 4HCK, 4LUD, 4LUE, 4ORZ, 4U5W, 5HCK
Identifiers
Aliases	HCK, JTK9, p59Hck, p61Hck, HCK proto-oncogene, Src family tyrosine kinase
External IDs	OMIM: 142370; MGI: 96052; HomoloGene: 20489; GeneCards: HCK; OMA:HCK - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	32,101,856 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	152,993,361 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; blood; ; spleen; ; bone marrow; ; appendix; ; trabecular bone; ; middle frontal gyrus; ; bone marrow cells; ; periodontal fiber;
	Top expressed in
	granulocyte; ; stroma of bone marrow; ; tibiofemoral joint; ; spleen; ; blood; ; rib; ; mesenteric lymph nodes; ; right lung lobe; ; transitional epithelium of urinary bladder; ; left lung;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; non-membrane spanning protein tyrosine kinase activity; kinase activity; protein binding; signaling receptor binding; ATP binding; protein tyrosine kinase activity; phosphotyrosine residue binding;
Cellular component	cytoplasm; cytosol; Golgi apparatus; cell projection; membrane; focal adhesion; extrinsic component of cytoplasmic side of plasma membrane; transport vesicle; cell junction; actin filament; caveola; lysosome; cytoskeleton; cytoplasmic vesicle; nucleus; nucleoplasm; plasma membrane;
Biological process	cell differentiation; leukocyte migration involved in immune response; positive regulation of actin filament polymerization; Fc-gamma receptor signaling pathway involved in phagocytosis; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; cytokine-mediated signaling pathway; interferon-gamma-mediated signaling pathway; immune system process; leukocyte degranulation; negative regulation of apoptotic process; mitigation of host defenses by virus; protein phosphorylation; cell adhesion; respiratory burst after phagocytosis; regulation of DNA-binding transcription factor activity; positive regulation of cell population proliferation; regulation of inflammatory response; regulation of cell shape; regulation of podosome assembly; peptidyl-tyrosine autophosphorylation; phagocytosis; integrin-mediated signaling pathway; protein autophosphorylation; peptidyl-tyrosine phosphorylation; regulation of phagocytosis; mesoderm development; inflammatory response; innate immune response-activating signal transduction; positive regulation of actin cytoskeleton reorganization; lipopolysaccharide-mediated signaling pathway; exocytosis; viral process; innate immune response;
	Sources:Amigo / QuickGO
Orthologs
	3055
	15162
	ENSG00000101336
	ENSMUSG00000003283
	P08631
	P08103
NM_002110; NM_001172129; NM_001172130; NM_001172131; NM_001172132;
	NM_001172133
	NM_001172117; NM_010407
NP_001165600; NP_001165601; NP_001165602; NP_001165603; NP_001165604;
	NP_002101
	NP_001165588; NP_034537
	Wikidata
View/Edit Human	View/Edit Mouse

Tyrosine-protein kinase HCK is an enzyme that in humans is encoded by the HCK gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000101336 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000003283 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Quintrell N, Lebo R, Varmus H, Bishop JM, Pettenati MJ, Le Beau MM, Diaz MO, Rowley JD (August 1987). "Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells". Mol Cell Biol. 7 (6): 2267–75. doi:10.1128/mcb.7.6.2267. PMC 365351. PMID 3496523.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000101336 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000003283 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid3496523-5] Quintrell N, Lebo R, Varmus H, Bishop JM, Pettenati MJ, Le Beau MM, Diaz MO, Rowley JD (August 1987). "Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells". Mol Cell Biol. 7 (6): 2267–75. doi:10.1128/mcb.7.6.2267. PMC 365351. PMID 3496523.

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