HDAC3

HDAC3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4A69
Identifiers
Aliases	HDAC3, HD3, RPD3, RPD3-2, histone deacetylase 3
External IDs	OMIM: 605166; MGI: 1343091; HomoloGene: 48250; GeneCards: HDAC3; OMA:HDAC3 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	141,636,870 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	38,088,069 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right adrenal cortex; ; left adrenal gland; ; left adrenal cortex; ; skin of leg; ; granulocyte; ; skin of abdomen; ; anterior pituitary; ; right ovary; ; right lobe of thyroid gland;
	Top expressed in
	spermatocyte; ; ventricular zone; ; genital tubercle; ; tail of embryo; ; superior frontal gyrus; ; muscle of thigh; ; lip; ; yolk sac; ; primary visual cortex; ; neural tube;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	NAD-dependent histone deacetylase activity (H3-K14 specific); transcription corepressor activity; histone deacetylase activity; protein deacetylase activity; transcription factor binding; histone deacetylase binding; chromatin binding; NF-kappaB binding; protein binding; enzyme binding; hydrolase activity; cyclin binding;
Cellular component	cytoplasm; histone deacetylase complex; cytosol; Golgi apparatus; plasma membrane; transcription repressor complex; nucleoplasm; spindle microtubule; nucleus; mitotic spindle;
Biological process	histone H3 deacetylation; positive regulation of protein phosphorylation; regulation of transcription, DNA-templated; regulation of protein stability; negative regulation of apoptotic process; negative regulation of transcription by RNA polymerase II; cellular response to fluid shear stress; transcription, DNA-templated; spindle assembly; protein deacetylation; negative regulation of JNK cascade; circadian rhythm; negative regulation of myotube differentiation; negative regulation of transcription, DNA-templated; histone deacetylation; positive regulation of TOR signaling; positive regulation of transcription by RNA polymerase II; negative regulation of nucleic acid-templated transcription; regulation of lipid metabolic process; chromatin organization; positive regulation of protein import into nucleus; histone H4 deacetylation; positive regulation of cold-induced thermogenesis; positive regulation of protein ubiquitination; circadian regulation of gene expression; regulation of circadian rhythm; rhythmic process;
	Sources:Amigo / QuickGO
Orthologs
	8841
	15183
	ENSG00000171720
	ENSMUSG00000024454
	O15379
	O88895
	NM_003883
	NM_010411
	NP_003874; NP_001341968; NP_001341969; NP_001341970
	NP_034541
	Wikidata
View/Edit Human	View/Edit Mouse

Histone deacetylase 3 is an enzyme encoded by the HDAC3 gene in both humans and mice.^[5]^[6]^[7]^[8]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000171720 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024454 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Emiliani S, Fischle W, Van Lint C, Al-Abed Y, Verdin E (April 1998). "Characterization of a human RPD3 ortholog, HDAC3". Proc Natl Acad Sci U S A. 95 (6): 2795–800. Bibcode:1998PNAS...95.2795E. doi:10.1073/pnas.95.6.2795. PMC 19648. PMID 9501169.
^ Dangond F, Hafler DA, Tong JK, Randall J, Kojima R, Utku N, Gullans SR (March 1998). "Differential display cloning of a novel human histone deacetylase (HDAC3) cDNA from PHA-activated immune cells". Biochem Biophys Res Commun. 242 (3): 648–52. doi:10.1006/bbrc.1997.8033. PMID 9464271.
^ Montgomery, Rusty L.; Potthoff, Matthew J.; Haberland, Michael; Qi, Xiaoxia; Matsuzaki, Satoshi; Humphries, Kenneth M.; Richardson, James A.; Bassel-Duby, Rhonda; Olson, Eric N. (2008-11-03). "Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice". Journal of Clinical Investigation. 118 (11): 3588–3597. doi:10.1172/jci35847. ISSN 0021-9738. PMC 2556240. PMID 18830415.
^ Bhaskara, Srividya; Chyla, Brenda J.; Amann, Joseph M.; Knutson, Sarah K.; Cortez, David; Sun, Zu-Wen; Hiebert, Scott W. (2008). "Deletion of Histone Deacetylase 3 Reveals Critical Roles in S Phase Progression and DNA Damage Control". Molecular Cell. 30 (1): 61–72. doi:10.1016/j.molcel.2008.02.030. PMC 2373760. PMID 18406327.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000171720 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024454 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9501169-5] Emiliani S, Fischle W, Van Lint C, Al-Abed Y, Verdin E (April 1998). "Characterization of a human RPD3 ortholog, HDAC3". Proc Natl Acad Sci U S A. 95 (6): 2795–800. Bibcode:1998PNAS...95.2795E. doi:10.1073/pnas.95.6.2795. PMC 19648. PMID 9501169.

[pmid9464271-6] Dangond F, Hafler DA, Tong JK, Randall J, Kojima R, Utku N, Gullans SR (March 1998). "Differential display cloning of a novel human histone deacetylase (HDAC3) cDNA from PHA-activated immune cells". Biochem Biophys Res Commun. 242 (3): 648–52. doi:10.1006/bbrc.1997.8033. PMID 9464271.

[7] Montgomery, Rusty L.; Potthoff, Matthew J.; Haberland, Michael; Qi, Xiaoxia; Matsuzaki, Satoshi; Humphries, Kenneth M.; Richardson, James A.; Bassel-Duby, Rhonda; Olson, Eric N. (2008-11-03). "Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice". Journal of Clinical Investigation. 118 (11): 3588–3597. doi:10.1172/jci35847. ISSN 0021-9738. PMC 2556240. PMID 18830415.

[8] Bhaskara, Srividya; Chyla, Brenda J.; Amann, Joseph M.; Knutson, Sarah K.; Cortez, David; Sun, Zu-Wen; Hiebert, Scott W. (2008). "Deletion of Histone Deacetylase 3 Reveals Critical Roles in S Phase Progression and DNA Damage Control". Molecular Cell. 30 (1): 61–72. doi:10.1016/j.molcel.2008.02.030. PMC 2373760. PMID 18406327.

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