HDAC4

HDAC4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2H8N, 2O94, 2VQJ, 2VQM, 2VQO, 2VQQ, 2VQV, 2VQW, 3UXG, 3UZD, 3V31, 4CBT, 4CBY, 5A2S
Identifiers
Aliases	HDAC4, AHO3, BDMR, HA6116, HD4, HDAC-4, HDAC-A, HDACA, histone deacetylase 4, NEDCHID
External IDs	OMIM: 605314; MGI: 3036234; HomoloGene: 55946; GeneCards: HDAC4; OMA:HDAC4 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	239,401,654 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	92,123,421 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; glutes; ; gastrocnemius muscle; ; tibialis anterior muscle; ; muscle of thigh; ; muscle layer of sigmoid colon; ; endothelial cell; ; deltoid muscle; ; Skeletal muscle tissue of biceps brachii; ; blood;
	Top expressed in
	otic vesicle; ; granulocyte; ; gastrula; ; Rostral migratory stream; ; dentate gyrus of hippocampal formation granule cell; ; muscle of thigh; ; lip; ; interventricular septum; ; muscle tissue; ; skeletal muscle tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	NAD-dependent histone deacetylase activity (H3-K14 specific); sequence-specific DNA binding; DNA binding; transcription corepressor activity; histone deacetylase activity; zinc ion binding; transcription factor binding; histone deacetylase binding; potassium ion binding; chromatin binding; metal ion binding; protein binding; protein kinase binding; hydrolase activity; protein deacetylase activity; identical protein binding; promoter-specific chromatin binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; SUMO transferase activity;
Cellular component	cytoplasm; histone deacetylase complex; neuromuscular junction; transcription repressor complex; sarcomere; Z discdkac; A band; actomyosin; nucleus; cytosol; nucleoplasm; protein-containing complex;
Biological process	positive regulation of reactive oxygen species biosynthetic process; histone H3 deacetylation; skeletal system development; chromatin remodeling; peptidyl-lysine deacetylation; regulation of cardiac muscle contraction by calcium ion signaling; negative regulation of glycolytic process; response to interleukin-1; regulation of transcription, DNA-templated; regulation of gene expression, epigenetic; cellular response to tumor necrosis factor; positive regulation of DNA-binding transcription factor activity; negative regulation of transcription by RNA polymerase II; positive regulation of protein sumoylation; negative regulation of DNA-binding transcription factor activity; negative regulation of osteoblast differentiation; transcription, DNA-templated; nervous system development; regulation of striated muscle cell differentiation; positive regulation of transcription, DNA-templated; positive regulation of smooth muscle cell migration; B cell activation; histone H4 deacetylation; cellular response to mechanical stimulus; positive regulation of neuron apoptotic process; cardiac muscle hypertrophy in response to stress; positive regulation of cell population proliferation; negative regulation of myotube differentiation; response to denervation involved in regulation of muscle adaptation; regulation of skeletal muscle fiber development; osteoblast development; B cell differentiation; cellular response to parathyroid hormone stimulus; inflammatory response; positive regulation of lamellipodium assembly; regulation of protein binding; negative regulation of transcription, DNA-templated; histone deacetylation; positive regulation of transcription by RNA polymerase II; negative regulation of cell population proliferation; positive regulation of smooth muscle cell proliferation; chromatin organization; negative regulation of pri-miRNA transcription by RNA polymerase II; protein deacetylation; protein sumoylation; positive regulation of male mating behavior;
	Sources:Amigo / QuickGO
Orthologs
	9759
	208727
	ENSG00000068024
	ENSMUSG00000026313
	P56524
	Q6NZM9
	NM_006037; NM_001378414; NM_001378415; NM_001378416; NM_001378417
	NM_207225
	NP_006028; NP_001365343; NP_001365344; NP_001365345; NP_001365346
	NP_997108
	Wikidata
View/Edit Human	View/Edit Mouse

Histone deacetylase 4, also known as HDAC4, is a protein that in humans is encoded by the HDAC4 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000068024 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026313 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Grozinger CM, Hassig CA, Schreiber SL (April 1999). "Three proteins define a class of human histone deacetylases related to yeast Hda1p". Proceedings of the National Academy of Sciences of the United States of America. 96 (9): 4868–73. Bibcode:1999PNAS...96.4868G. doi:10.1073/pnas.96.9.4868. PMC 21783. PMID 10220385.
^ Fischle W, Emiliani S, Hendzel MJ, Nagase T, Nomura N, Voelter W, Verdin E (April 1999). "A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1p". The Journal of Biological Chemistry. 274 (17): 11713–20. doi:10.1074/jbc.274.17.11713. PMID 10206986.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000068024 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026313 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10220385-5] Grozinger CM, Hassig CA, Schreiber SL (April 1999). "Three proteins define a class of human histone deacetylases related to yeast Hda1p". Proceedings of the National Academy of Sciences of the United States of America. 96 (9): 4868–73. Bibcode:1999PNAS...96.4868G. doi:10.1073/pnas.96.9.4868. PMC 21783. PMID 10220385.

[pmid10206986-6] Fischle W, Emiliani S, Hendzel MJ, Nagase T, Nomura N, Voelter W, Verdin E (April 1999). "A new family of human histone deacetylases related to Saccharomyces cerevisiae HDA1p". The Journal of Biological Chemistry. 274 (17): 11713–20. doi:10.1074/jbc.274.17.11713. PMID 10206986.

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