HGS (gene)

HGS
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2D3G, 3F1I, 3OBQ, 3ZYQ, 4AVX
Identifiers
Aliases	HGS, HRS, hepatocyte growth factor-regulated tyrosine kinase substrate
External IDs	OMIM: 604375; MGI: 104681; HomoloGene: 37954; GeneCards: HGS; OMA:HGS - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	81,703,138 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	120,374,805 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; sural nerve; ; granulocyte; ; right testis; ; left testis; ; right hemisphere of cerebellum; ; anterior pituitary; ; canal of the cervix; ; skin of abdomen; ; mucosa of transverse colon;
	Top expressed in
	Ileal epithelium; ; entorhinal cortex; ; perirhinal cortex; ; lactiferous gland; ; choroid plexus of fourth ventricle; ; CA3 field; ; seminiferous tubule; ; spermatid; ; granulocyte; ; spermatocyte;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein domain specific binding; metal ion binding; protein binding; ubiquitin-like protein ligase binding;
Cellular component	endosome; early endosome membrane; multivesicular body membrane; intracellular membrane-bounded organelle; membrane; early endosome; extracellular exosome; cytoplasm; lysosome; cytosol; ESCRT-0 complex;
Biological process	protein localization to membrane; protein targeting to lysosome; negative regulation of epidermal growth factor receptor signaling pathway; membrane invagination; multivesicular body assembly; endosomal transport; positive regulation of gene expression; regulation of protein catabolic process; protein transport; regulation of MAP kinase activity; positive regulation of exosomal secretion; intracellular protein transport; signal transduction; negative regulation of cell population proliferation; negative regulation of receptor signaling pathway via JAK-STAT; macroautophagy; protein deubiquitination; membrane organization; transport; negative regulation of platelet-derived growth factor receptor signaling pathway; negative regulation of angiogenesis; negative regulation of vascular endothelial growth factor receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	9146
	15239
	ENSG00000185359
	ENSMUSG00000025793
	O14964
	Q99LI8
	NM_004712
	NM_001159328; NM_008244
	NP_004703
	NP_001152800; NP_032270
	Wikidata
View/Edit Human	View/Edit Mouse

Hepatocyte growth factor-regulated tyrosine kinase substrate is an enzyme that in humans is encoded by the HGS gene.^[5]^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000185359 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025793 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Asao H, Sasaki Y, Arita T, Tanaka N, Endo K, Kasai H, Takeshita T, Endo Y, Fujita T, Sugamura K (1997). "Hrs Is Associated with STAM, a Signal-transducing Adaptor Molecule: Its suppressive effect on cytokine-induced cell growth". Journal of Biological Chemistry. 272 (52): 32785–32791. doi:10.1074/jbc.272.52.32785. ISSN 0021-9258. PMID 9407053.
^ Lu L, Komada M, Kitamura N (August 1998). "Human Hrs, a tyrosine kinase substrate in growth factor-stimulated cells: cDNA cloning and mapping of the gene to chromosome 17". Gene. 213 (1–2): 125–32. doi:10.1016/S0378-1119(98)00184-X. PMID 9630564.
^ "Entrez Gene: HGS hepatocyte growth factor-regulated tyrosine kinase substrate".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000185359 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025793 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9407053-5] Asao H, Sasaki Y, Arita T, Tanaka N, Endo K, Kasai H, Takeshita T, Endo Y, Fujita T, Sugamura K (1997). "Hrs Is Associated with STAM, a Signal-transducing Adaptor Molecule: Its suppressive effect on cytokine-induced cell growth". Journal of Biological Chemistry. 272 (52): 32785–32791. doi:10.1074/jbc.272.52.32785. ISSN 0021-9258. PMID 9407053.

[pmid9630564-6] Lu L, Komada M, Kitamura N (August 1998). "Human Hrs, a tyrosine kinase substrate in growth factor-stimulated cells: cDNA cloning and mapping of the gene to chromosome 17". Gene. 213 (1–2): 125–32. doi:10.1016/S0378-1119(98)00184-X. PMID 9630564.

[entrez-7] "Entrez Gene: HGS hepatocyte growth factor-regulated tyrosine kinase substrate".

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