HHV Infected Cell Polypeptide 0

Structure of the ring-finger domain of ICP0

Human Herpes Virus (HHV) Infected Cell Polypeptide 0 (ICP0) is a protein, encoded by the DNA of herpes viruses. It is produced by herpes viruses during the earliest stage of infection, when the virus has recently entered the host cell; this stage is known as the immediate-early or α ("alpha") phase of viral gene expression.[1] During these early stages of infection, ICP0 protein is synthesized and transported to the nucleus of the infected host cell. Here, ICP0 promotes transcription from viral genes, disrupts structures in the nucleus known as nuclear dots or promyelocytic leukemia (PML) nuclear bodies,[2] and alters the expression of host and viral genes in combination with a neuron specific protein.[3][4] At later stages of cellular infection, ICP0 relocates to the cell cytoplasm to be incorporated into new virion particles.[5]

  1. ^ Edward K. Wagner. "Herpes simplex virus Research". Archived from the original on December 12, 2012. Retrieved Oct 25, 2007.
  2. ^ Cite error: The named reference PMID15163746 was invoked but never defined (see the help page).
  3. ^ Cite error: The named reference PMID15897453 was invoked but never defined (see the help page).
  4. ^ Cite error: The named reference PMID17555596 was invoked but never defined (see the help page).
  5. ^ Sedlackova L, Rice SA (January 2008). "Herpes simplex virus type 1 immediate-early protein ICP27 is required for efficient incorporation of ICP0 and ICP4 into virions". Journal of Virology. 82 (1): 268–77. doi:10.1128/JVI.01588-07. PMC 2224399. PMID 17959681.