HIST1H1B

H1-5
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesH1-5, H1, H1.5, H1B, H1F5, H1s-3, histone cluster 1, H1b, histone cluster 1 H1 family member b, HIST1H1B, H1.5 linker histone, cluster member
External IDsOMIM: 142711; MGI: 1861461; HomoloGene: 136789; GeneCards: H1-5; OMA:H1-5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005322

NM_020034

RefSeq (protein)

NP_005313

NP_064418

Location (UCSC)Chr 6: 27.87 – 27.87 MbChr 13: 21.96 – 21.96 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Histone H1.5 is a protein that in humans is encoded by the HIST1H1B gene.[5][6][7][8]

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3.[8]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000184357Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000058773Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Albig W, Meergans T, Doenecke D (Mar 1997). "Characterization of the H1.5 gene completes the set of human H1 subtype genes". Gene. 184 (2): 141–8. doi:10.1016/S0378-1119(96)00582-3. PMID 9031620.
  6. ^ Albig W, Kioschis P, Poustka A, Meergans K, Doenecke D (Apr 1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399.
  7. ^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
  8. ^ a b "Entrez Gene: HIST1H1B histone cluster 1, H1b".