Enzyme involved with peptide bond hydrolysis in retroviruses
HIV-1 protease or PR is a retroviral aspartyl protease (retropepsin), an enzyme involved with peptide bond hydrolysis in retroviruses, that is essential for the life-cycle of HIV , the retrovirus that causes AIDS .[ 1] [ 2] HIV-1 PR cleaves newly synthesized polyproteins (namely, Gag and Gag-Pol [ 3] ) at nine cleavage sites to create the mature protein components of an HIV virion , the infectious form of a virus outside of the host cell.[ 4] Without effective HIV-1 PR, HIV virions remain uninfectious.[ 5] [ 6]
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