The HIV-1 Rev response element (RRE) is a highly structured, ~350 nucleotide RNA segment present in the Env coding region of unspliced and partially spliced viral mRNAs. In the presence of the HIV-1 accessory protein Rev, HIV-1 mRNAs that contain the RRE can be exported from the nucleus to the cytoplasm for downstream events such as translation and virion packaging.[1][2]
- ^ Cullen, Bryan R (2003). "Nuclear mRNA export: Insights from virology". Trends in Biochemical Sciences. 28 (8): 419–424. doi:10.1016/S0968-0004(03)00142-7. PMID 12932730.
- ^ Pollard, Victoria W.; Malim, Michael H. (1998). "The Hiv-1 Rev Protein". Annual Review of Microbiology. 52: 491–532. doi:10.1146/annurev.micro.52.1.491. PMID 9891806.