HKDC1

HKDC1
Identifiers
Aliases	HKDC1, hexokinase domain containing 1, RP92
External IDs	OMIM: 617221; MGI: 2384910; HomoloGene: 128937; GeneCards: HKDC1; OMA:HKDC1 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	69,267,552 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	62,258,270 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; duodenum; ; testicle; ; mucosa of ileum; ; mucosa of transverse colon; ; islet of Langerhans; ; gallbladder; ; body of pancreas; ; right uterine tube; ; human kidney;
	Top expressed in
	renal calyx; ; intestinal villus; ; epithelium of small intestine; ; jejunum; ; lateral recess; ; duodenum; ; ileum; ; yolk sac; ; lateral ventricle; ; choroid plexus of lateral ventricle;
	More reference expression data
	n/a
Gene ontology
Molecular function	kinase activity; transferase activity; nucleotide binding; fructokinase activity; mannokinase activity; glucokinase activity; hexokinase activity; ATP binding; phosphotransferase activity, alcohol group as acceptor; glucose binding;
Cellular component	cytosol; mitochondrion;
Biological process	cellular glucose homeostasis; hexose metabolic process; glycolytic process; carbohydrate phosphorylation; phosphorylation; glucose 6-phosphate metabolic process; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	80201
	216019
	ENSG00000156510
	ENSMUSG00000020080
	Q2TB90
	Q91W97
	NM_025130
	NM_145419
	NP_079406
	NP_663394
	Wikidata
View/Edit Human	View/Edit Mouse

Hexokinase domain containing 1 (HKDC1) is an enzyme which in humans is encoded by the HKDC1 gene on chromosome 10.^[5] It is a recently discovered hexokinase isoform that likely phosphorylates glucose in maternal metabolism during pregnancy.^[6]^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000156510 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020080 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: HKDC1 hexokinase domain containing 1".
^ Guo C, Ludvik AE, Arlotto ME, Hayes MG, Armstrong LL, Scholtens DM, et al. (February 2015). "Coordinated regulatory variation associated with gestational hyperglycaemia regulates expression of the novel hexokinase HKDC1". Nature Communications. 6: 6069. Bibcode:2015NatCo...6.6069G. doi:10.1038/ncomms7069. PMC 4318120. PMID 25648650.
^ Hayes MG, Urbanek M, Hivert MF, Armstrong LL, Morrison J, Guo C, et al. (September 2013). "Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies". Diabetes. 62 (9): 3282–91. doi:10.2337/db12-1692. PMC 3749326. PMID 23903356.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000156510 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000020080 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: HKDC1 hexokinase domain containing 1".

[pmid25648650-6] Guo C, Ludvik AE, Arlotto ME, Hayes MG, Armstrong LL, Scholtens DM, et al. (February 2015). "Coordinated regulatory variation associated with gestational hyperglycaemia regulates expression of the novel hexokinase HKDC1". Nature Communications. 6: 6069. Bibcode:2015NatCo...6.6069G. doi:10.1038/ncomms7069. PMC 4318120. PMID 25648650.

[pmid23903356-7] Hayes MG, Urbanek M, Hivert MF, Armstrong LL, Morrison J, Guo C, et al. (September 2013). "Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies". Diabetes. 62 (9): 3282–91. doi:10.2337/db12-1692. PMC 3749326. PMID 23903356.

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