HLA-A11

HLA-A11
(MHC Class I, A cell surface antigen)
Rendering of A11 (A*1101-B2M) in complex with HBV peptide homologue2HN7​ HLA-A11 'alpha chain' (Cyan), β2-microglobulin (Rose), HBV peptide (yellow).
About
Proteintransmembrane receptor/ligand
Structureαβ heterodimer
SubunitsHLA-A*11--, β2-microglobulin
Older namesHL-A11
Subtypes
Subtype
allele
Available structures
A11E, A11.1 *1101 2hn7​, 1x7q​, 1qvo​, 1q94
A11K, A11.2 *1102
Rare alleles
Subtype
allele
Available structures
A11.3 *1103
A11.4 *1104
Alleles link-out to IMGT/HLA database at EBI

HLA-A11 (A11) is a human leukocyte antigen serotype within HLA-A "A" serotype group. The serotype is determined by the antibody recognition of α11 subset of HLA-A α-chains. For A11, the alpha "A" chain are encoded by the HLA-A*11 allele group and the β-chain are encoded by B2M locus.[1] This group currently is dominated by A*1101. A11 and A*11 are almost synonymous in meaning. A11 is more common in East Asia than elsewhere, it is part of several long haplotypes that appear to have been frequent in the ancient peoples of Asia.[2]

  1. ^ Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
  2. ^ de Campos-Lima PO, Levitsky V, Brooks J, et al. (April 1994). "T cell responses and virus evolution: loss of HLA A11-restricted CTL epitopes in Epstein-Barr virus isolates from highly A11-positive populations by selective mutation of anchor residues". J. Exp. Med. 179 (4): 1297–305. doi:10.1084/jem.179.4.1297. PMC 2191457. PMID 7511684.