HLA-A24 | ||||||||||
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(MHC Class I, A cell surface antigen) | ||||||||||
About | ||||||||||
Protein | transmembrane receptor/ligand | |||||||||
Structure | αβ heterodimer | |||||||||
Subunits | HLA-A*24--, β2-microglobulin | |||||||||
Older names | HL-A9 | |||||||||
Subtypes | ||||||||||
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Alleles link-out to IMGT/HLA database at EBI |
HLA-A24 (A24) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α24 subset of HLA-A α-chains. For A24, the alpha, "A", chain are encoded by the HLA-A*24 allele group and the β-chain are encoded by B2M locus.[1] This group currently is dominated by A*2402. A24 and A*24 are almost synonymous in meaning. A24 is a split antigen of the broad antigen HLA-A9 and it is a sister serotype of HLA-A23.
A*2402 has one of the highest "A" frequencies identified for a number of peoples, including Papua New Guineans, Indigenous Taiwanese (Eastern Tribals), Yupik and Greenland [Aleuts]. It is common over much of Southeastern Asia. In Eurasia it is least common in Ireland, and A24 is relatively uncommon in Africa except North Africa and Kenya.