HLA-A26

HLA-A26
HLA-A26
(MHC Class I, A cell surface antigen)
	HLA-A26
About
Protein	transmembrane receptor/ligand
Structure	αβ heterodimer
Subunits	HLA-A*2601, β2-microglobulin
Older names	A10
Subtypes
Subtype
Subtype	allele
A26.1	*2601
{{{cNick2}}}	*26{{{cAllele2}}}
{{{cNick3}}}	*26{{{cAllele3}}}
{{{cNick4}}}	*26{{{cAllele4}}}
Rare alleles
Subtype
Subtype	allele
A26.2	*2602
A26.4	*2603
-	*2605
	Alleles link-out to IMGT/HLA database at EBI

HLA-A26 (A26) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α²⁶ subset of HLA-A α-chains. For A26, the alpha "A" chain are encoded by the HLA-A*26 allele group and the β-chain are encoded by B2M locus.^[1] This group currently is dominated by A*2601. A26 and A*26 are almost synonymous in meaning. A26 is a split antigen of the broad antigen serotype A10. A26 is a sister serotype of A25, A34, A43, and A66.

A26 is more common in West Pacific Rim (Taiwan to Hokkaido).

Serotype

A26 recognition of some HLA A*26 gene products^[2]
A*26	A26	A10	Sample
allele	%	%	size (N)
*2601	97	2	1730
*2602	81	0	31
*2603	68	8	38
*2605	90	0	10

A26 reasonably good serotyping with no overt false recognition..

^ Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
^ Allele Query Form IMGT/HLA - European Bioinformatics Institute

[pmid77067-1] Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.

[2] Allele Query Form IMGT/HLA - European Bioinformatics Institute

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