 | This article may be too technical for most readers to understand. (May 2017) |
| HLA-A3 | ||||||||||
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| (MHC Class I, A cell surface antigen) | ||||||||||
 HLA-A3 | ||||||||||
| About | ||||||||||
| Protein | transmembrane receptor/ligand | |||||||||
| Structure | αβ heterodimer | |||||||||
| Subunits | HLA-A*03--, β2-microglobulin | |||||||||
| Older names | HL-A3 | |||||||||
| Subtypes | ||||||||||
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| Rare alleles | ||||||||||
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| Alleles link-out to IMGT/HLA database at EBI | ||||||||||
HLA-A3 (A3) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α3 subset of HLA-A α-chains. For A3, the alpha, "A", chain are encoded by the HLA-A*03 allele group and the β-chain are encoded by B2M locus.[1] This group currently is dominated by A*03:01. A3 and A*03 are almost synonymous in meaning. A3 is more common in Europe, it is part of the longest known multigene haplotype, A3~B7~DR15~DQ6.[2]
- ^ Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
- ^ Horton R, Gibson R, Coggill P, et al. (January 2008). "Variation analysis and gene annotation of eight MHC haplotypes: the MHC Haplotype Project". Immunogenetics. 60 (1): 1–18. doi:10.1007/s00251-007-0262-2. PMC 2206249. PMID 18193213.