HLA-A31

HLA-A31
(MHC Class I, A cell surface antigen)
HLA-A31
About
Proteintransmembrane receptor/ligand
Structureαβ heterodimer
SubunitsHLA-A*3101, β2-microglobulin
Older namesA19
Subtypes
Subtype
allele
Available structures
A31 *3101
{{{cNick2}}} *31{{{cAllele2}}}
{{{cNick3}}} *31{{{cAllele3}}}
{{{cNick4}}} *31{{{cAllele4}}}
Rare alleles
Subtype
allele
Available structures
A31.2 *3102
{{{rnick2}}} *31{{{rallele2}}}
{{{rnick3}}} *31{{{rallele3}}}
Alleles link-out to IMGT/HLA database at EBI

HLA-A31 (A31) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α31 subset of HLA-A α-chains. For A31, the alpha "A" chain are encoded by the HLA-A*31 allele group and the β-chain are encoded by B2M locus.[1] This group currently is dominated by A*3101. A31 and A*31 are almost synonymous in meaning. A31 is a split antigen of the broad antigen serotype A19. A31 is a sister serotype of A29A30A32A33, and A74.

A31 is more common in South and Central America.

Serotype

[edit]
A31 recognition of some HLA A*31 gene products[2]
A*31 A31 A19 A30 Sample
allele % % % size (N)
*3101 90 1 3 3517
*3102 100 0 0 11


There is substantive false reaction of A30 with A*3101, otherwise serological identification is good.

  1. ^ Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
  2. ^ Allele Query Form IMGT/HLA - European Bioinformatics Institute